2023
Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection
Chaguza C, Hahn A, Petrone M, Zhou S, Ferguson D, Breban M, Pham K, Peña-Hernández M, Castaldi C, Hill V, Initiative Y, Billig K, Earnest R, Fauver J, Kalinch C, Kerantzas N, Koch T, De Kumar B, Landry M, Ott I, Peaper D, Tikhonova I, Vogels C, Schulz W, Swanstrom R, Roberts S, Grubaugh N. Accelerated SARS-CoV-2 intrahost evolution leading to distinct genotypes during chronic infection. Cell Reports Medicine 2023, 4: 100943. PMID: 36791724, PMCID: PMC9906997, DOI: 10.1016/j.xcrm.2023.100943.Peer-Reviewed Original ResearchConceptsChronic infectionEvolutionary ratesGenetic diversityIntrahost evolutionDistinct genotypesHigher viral genome copiesVirus evolutionary ratesSARS-CoV-2 evolutionUntreated chronic infectionAdvantageous mutationsNucleotide substitutionsViral genome copiesDivergent variantsInfection hypothesisVariant emergenceViral populationsInfectious virusInfectionHallmark changesGenome copiesDifferent genotypesDiversityGenotypesTemporal dynamicsEvolutionAnalysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center
Roberts S, Faruq R, Wilkinson A, Pashankar D, Russi M, Khokhar B, Martinello R. Analysis of Failure Rates for COVID-19 Entrance Screening at a US Academic Medical Center. JAMA Internal Medicine 2023, 183: 84-86. PMID: 36441528, PMCID: PMC9706395, DOI: 10.1001/jamainternmed.2022.5426.Peer-Reviewed Original Research
2022
An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era
Roberts SC, Palacios C, Grubaugh ND, Alpert T, Ott IM, Breban MI, Initiative Y, Martinello RA, Smith C, Davis MW, Mcmanus D, Tirmizi S, Topal JE, Azar MM, Malinis M. An outbreak of SARS‐CoV‐2 on a transplant unit in the early vaccination era. Transplant Infectious Disease 2022, 24: e13782. PMID: 34969164, DOI: 10.1111/tid.13782.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Infection prevention practicesSARS-CoV-2 outbreakTransplant unitCOVID-19-associated morbiditySolid organ transplant recipientsSARS-CoV-2 vaccinationPrevention practicesHospital day 18Potential index casesOrgan transplant recipientsInfection prevention behaviorsMonoclonal antibody therapyCOVID-19SARS-CoV-2 clustersHospital staff membersWhole-genome sequencingAsymptomatic patientsTransplant recipientsPositive patientsAtypical presentationImmunocompromised patientsAntibody therapyVaccination eraDisease progression
2021
Correlation of healthcare worker vaccination with inpatient healthcare-associated coronavirus disease 2019 (COVID-19)
Roberts SC, Aniskiewicz MJ, Choi SJ, Pettker CM, Martinello RA. Correlation of healthcare worker vaccination with inpatient healthcare-associated coronavirus disease 2019 (COVID-19). Infection Control And Hospital Epidemiology 2021, 43: 524-525. PMID: 34544506, PMCID: PMC8485009, DOI: 10.1017/ice.2021.414.Peer-Reviewed Original ResearchEpidemiology, Infection Prevention, Testing Data, and Clinical Outcomes of COVID-19 on Five Inpatient Psychiatric Units in a large Academic Medical Center
Li L, Roberts SC, Kulp W, Wing A, Barnes T, Colandrea N, Klink B, Fortunati F, Martinello R. Epidemiology, Infection Prevention, Testing Data, and Clinical Outcomes of COVID-19 on Five Inpatient Psychiatric Units in a large Academic Medical Center. Psychiatry Research 2021, 298: 113776. PMID: 33571800, PMCID: PMC7987366, DOI: 10.1016/j.psychres.2021.113776.Peer-Reviewed Original ResearchConceptsInpatient psychiatric unitLarge academic medical centerAcademic medical centerPsychiatric unitMedical CenterCOVID-19Retrospective cohort analysisEmergency room visitsInpatient psychiatric facilityLow patientsClinical outcomesRoom visitsHospitalized individualsInfection preventionStudy populationCohort analysisPrevention strategiesAdmission statusTriage protocolDiverse patientsInfection rateMental illnessPsychiatric facilitiesDemographic dataPatientsMass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel
Roberts SC, Peaper DR, Thorne CD, Sussman LS, Murray TS, Choi SJ, Pettker CM, Russi MB, Martinello RA. Mass severe acute respiratory coronavirus virus 2 (SARS-CoV-2) testing of asymptomatic healthcare personnel. Infection Control And Hospital Epidemiology 2021, 42: 1-2. PMID: 33487206, PMCID: PMC7853752, DOI: 10.1017/ice.2021.9.Peer-Reviewed Original Research
2020
A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways
Lorenzo-Redondo R, Nam HH, Roberts SC, Simons LM, Jennings LJ, Qi C, Achenbach CJ, Hauser AR, Ison MG, Hultquist JF, Ozer EA. A clade of SARS-CoV-2 viruses associated with lower viral loads in patient upper airways. EBioMedicine 2020, 62: 103112. PMID: 33186810, PMCID: PMC7655495, DOI: 10.1016/j.ebiom.2020.103112.Peer-Reviewed Original ResearchConceptsPatient's upper airwayViral loadSARS-CoV-2Upper airwayHighest average viral loadSARS-CoV-2 infectionTranslational Research AwardTime of diagnosisAverage viral loadCOVID-19 patientsLow viral loadComprehensive cancer centerCoronavirus disease 2019SARS-CoV-2 isolatesSARS-CoV-2 virusClade 1 virusesClade 2 virusesRelative viral loadVirologic featuresClinical characteristicsClinical parametersCancer CenterDistinct viral cladesClinical significanceTranslational Science Institute