2018
The Cholinergic System as a Treatment Target for Opioid Use Disorder
Jensen KP, DeVito EE, Yip S, Carroll KM, Sofuoglu M. The Cholinergic System as a Treatment Target for Opioid Use Disorder. CNS Drugs 2018, 32: 981-996. PMID: 30259415, PMCID: PMC6314885, DOI: 10.1007/s40263-018-0572-y.Peer-Reviewed Original ResearchConceptsCholinergic systemUse disordersTreatment targetsOpioid use disorder epidemicCentral nervous system functionTreatment of OUDEffects of acetylcholineOpioid use disorderTobacco use disorderNervous system functionOpioid medicationsDegrade acetylcholineCurrent treatmentOpioid overdosesPreclinical studiesMedicationsAcetylcholineCholinesterase inhibitorsAlzheimer's diseaseNew treatmentsAccidental deathGlobal healthTreatmentOUDDisease
2017
Reward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation
Garrison KA, Yip SW, Balodis IM, Carroll KM, Potenza MN, Krishnan-Sarin S. Reward-related frontostriatal activity and smoking behavior among adolescents in treatment for smoking cessation. Drug And Alcohol Dependence 2017, 177: 268-276. PMID: 28651213, PMCID: PMC5564393, DOI: 10.1016/j.drugalcdep.2017.03.035.Peer-Reviewed Original ResearchConceptsAdolescent smokersReward anticipationNeural responsesMonetary incentive delay taskBehavioral Activation ScaleIncentive delay taskNeural reward systemVentral striatal activationCessation treatmentMedial prefrontal cortexBilateral nucleus accumbensNeural correlatesSmoking cessation treatmentActivation ScalesBehavioral inhibitionFrontostriatal responseDelay taskFrontostriatal activityAdolescent nonsmokersStriatal activationPrefrontal cortexEffective smoking cessation interventionsReward systemSmoking cessation interventionTobacco use disorder