Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis
Weiss S, Darvishian F, Tadepalli J, Shapiro R, Golfinos J, Pavlick A, Polsky D, Kirchhoff T, Osman I. Somatic and germline analyses of a long term melanoma survivor with a recurrent brain metastasis. BMC Cancer 2015, 15: 926. PMID: 26597176, PMCID: PMC4657192, DOI: 10.1186/s12885-015-1927-0.Peer-Reviewed Original ResearchConceptsMelanoma brain metastasesRecurrent brain metastasesBrain metastasesOverall survivalLong-term melanoma survivorsSingle nucleotide polymorphismsYear old manIndividual patient's tumorGenetic variantsMelanoma patientsMelanoma survivorsPrognostic informationFavorable outcomeNRAS wild typePatient outcomesConclusionsOur dataPatient tumorsImmune functionBrain tumorsExtended survivalOlder menPatientsClinical scenariosGermline analysisTherapeutic interventionsRevisiting determinants of prognosis in cutaneous melanoma
Weiss SA, Hanniford D, Hernando E, Osman I. Revisiting determinants of prognosis in cutaneous melanoma. Cancer 2015, 121: 4108-4123. PMID: 26308244, PMCID: PMC4666819, DOI: 10.1002/cncr.29634.Peer-Reviewed Original ResearchConceptsDeterminants of prognosisCutaneous melanomaStaging systemCurrent staging modelsCurrent staging systemLymph node spreadPrimary tumor thicknessAmerican Joint CommitteeCancer (AJCC) staging systemPresence of ulcerationPrimary cutaneous melanomaUseful prognostic biomarkerMelanoma staging systemNew prognostic toolClinical surveillance strategiesAdjuvant therapyAdvanced diseaseDistant metastasisPatient selectionNode spreadSurvival outcomesTumor thicknessImmunologic markersPatient prognosisPatient outcomes