A Genetic Code Expansion‐Derived Molecular Beacon for the Detection of Intracellular Amyloid‐β Peptide Generation
Sappakhaw K, Jantarug K, Slavoff S, Israsena N, Uttamapinant C. A Genetic Code Expansion‐Derived Molecular Beacon for the Detection of Intracellular Amyloid‐β Peptide Generation. Angewandte Chemie 2020, 133: 3980-3985. PMID: 38504667, PMCID: PMC10946459, DOI: 10.1002/ange.202010703.Peer-Reviewed Original ResearchDiverse biological functionsAmyloid precursor proteinProteolytic proteoformsEndocytic pathwayGenetic taggingBiological functionsProtein precursorLiving cellsProteolytic processingMolecular beacon designPrecursor proteinCellular studiesLabeling strategyProteoformsMolecular beaconsAmyloid-β peptide generationBiogenesisImportant rolePeptide generationBeacon designPolypeptideReporterProteinAlzheimer's diseasePathway