Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling
Lichenstein SD, Scheinost D, Potenza MN, Carroll KM, Yip SW. Dissociable neural substrates of opioid and cocaine use identified via connectome-based modelling. Molecular Psychiatry 2019, 26: 4383-4393. PMID: 31719641, PMCID: PMC7214212, DOI: 10.1038/s41380-019-0586-y.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidBrainCocaineCocaine-Related DisordersConnectomeHumansMagnetic Resonance ImagingOpioid-Related DisordersConceptsBrain statesDissociable neural substratesMultiple brain statesSubstance use outcomesHealthy comparison subjectsWhole-brain approachFMRI scanningFrontoparietal networkNeural substratesSubstance use treatmentNeural mechanismsDifferent brain statesFurther clinical relevanceDefault modeFMRI dataSubject replicationTreatment approachesReduced connectivityUse outcomesComparison subjectsNetwork strengthUse disordersSensory networksTreatment respondersSensory connectivity