2021
Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation
Tyler PM, Bucklin ML, Zhao M, Maher TJ, Rice AJ, Ji W, Warner N, Pan J, Morotti R, McCarthy P, Griffiths A, van Rossum AMC, Hollink IHIM, Dalm VASH, Catanzaro J, Lakhani SA, Muise AM, Lucas CL. Human autoinflammatory disease reveals ELF4 as a transcriptional regulator of inflammation. Nature Immunology 2021, 22: 1118-1126. PMID: 34326534, PMCID: PMC8985851, DOI: 10.1038/s41590-021-00984-4.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalgranulin ADNA-Binding ProteinsFemaleGene Expression RegulationHereditary Autoinflammatory DiseasesHumansInflammatory Bowel DiseasesInterleukin 1 Receptor Antagonist ProteinLipocalin-2LipopolysaccharidesMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutTh17 CellsTranscription FactorsTranscription, GeneticTriggering Receptor Expressed on Myeloid Cells-1ConceptsInterleukin-1Inflammatory bowel disease (IBD) characteristicsInflammatory immune cellsHuman inflammatory disordersAnti-inflammatory genesTumor necrosis factorHuman autoinflammatory diseasesInnate stimuliHyperinflammatory responseMale patientsNeutrophil chemoattractantDisease characteristicsInflammatory disordersMucosal diseaseImmune cellsInflammation amplifierNecrosis factorUnrelated male patientsAutoinflammatory diseasesMouse modelBroad translational relevanceTranslational relevanceInflammationFunction variantsMouse macrophages
2006
Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis
Lakhani SA, Masud A, Kuida K, Porter GA, Booth CJ, Mehal WZ, Inayat I, Flavell RA. Caspases 3 and 7: Key Mediators of Mitochondrial Events of Apoptosis. Science 2006, 311: 847-851. PMID: 16469926, PMCID: PMC3738210, DOI: 10.1126/science.1115035.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisApoptosis Inducing FactorBcl-2-Associated X ProteinCaspase 3Caspase 7CaspasesCell NucleusCell ShapeCell SurvivalCells, CulturedCytochromes cDNA FragmentationFemaleFibroblastsHeartHeart Defects, CongenitalMaleMiceMice, Inbred C57BLMice, KnockoutMitochondriaMitochondrial MembranesPermeabilityT-LymphocytesConceptsApoptosis-inducing factorMitochondrial eventsDownstream effector caspasesDeath receptor-mediated apoptosisCytochrome c releaseCaspase-3Receptor-mediated apoptosisDefective nuclear translocationEarly apoptotic eventsMitochondrial membrane potentialEffector caspasesBax translocationC releaseCardiac developmentApoptotic eventsCaspase-7Upstream signalsNuclear translocationApoptosisMembrane potentialCritical mediatorKey mediatorTranslocationCaspasesEffectors