2014
Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA
Rongvaux A, Jackson R, Harman CC, Li T, West AP, de Zoete MR, Wu Y, Yordy B, Lakhani SA, Kuan CY, Taniguchi T, Shadel GS, Chen ZJ, Iwasaki A, Flavell RA. Apoptotic Caspases Prevent the Induction of Type I Interferons by Mitochondrial DNA. Cell 2014, 159: 1563-1577. PMID: 25525875, PMCID: PMC4272443, DOI: 10.1016/j.cell.2014.11.037.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApoptosisCaspasesDNA, MitochondrialInflammationInterferon Type IMiceMice, KnockoutSignal TransductionVirus DiseasesConceptsMitochondrial outer membrane permeabilizationCell deathOuter membrane permeabilizationType I interferonDNA-dependent activationCaspase-dependent mannerI interferonCGAS/STING pathwayMitochondrial DNAApoptotic caspasesMembrane permeabilizationActive caspasesProapoptotic caspasesMitochondriaCaspasesSTING pathwayIFN responseAntiviral immunityCentral roleDual controlPathwayProinflammatory typeInductionCellsActivation
2003
Toll-like receptor signaling in sepsis
Lakhani SA, Bogue CW. Toll-like receptor signaling in sepsis. Current Opinion In Pediatrics 2003, 15: 278-282. PMID: 12806257, DOI: 10.1097/00008480-200306000-00009.Peer-Reviewed Original ResearchMeSH KeywordsHumansLipopolysaccharidesMembrane GlycoproteinsReceptors, Cell SurfaceSepsisSignal TransductionToll-Like Receptor 4Toll-Like ReceptorsConceptsToll-like receptorsBacterial sepsisPediatric intensive care unitIntensive care unitPotential therapeutic approachPotential therapeutic strategySystemic inflammationCare unitMammalian immune systemInflammatory responseTLR signalingTherapeutic approachesTherapeutic strategiesDisease processSepsisImmune systemLPS responseBacterial lipopolysaccharideMajor causeMolecular patternsReceptorsOngoing evaluationMolecular biologyLipopolysaccharideMorbidity