Cytotoxic T-Lymphocyte-Associated Protein 4 Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation
Le Coz C, Nolan BE, Trofa M, Kamsheh AM, Khokha MK, Lakhani SA, Novelli A, Zackai EH, Sullivan KE, Briuglia S, Bhatti TR, Romberg N. Cytotoxic T-Lymphocyte-Associated Protein 4 Haploinsufficiency-Associated Inflammation Can Occur Independently of T-Cell Hyperproliferation. Frontiers In Immunology 2018, 9: 1715. PMID: 30087679, PMCID: PMC6066513, DOI: 10.3389/fimmu.2018.01715.Peer-Reviewed Original ResearchT cellsInflammatory diseasesLymphoid cellsT-lymphocyte-associated protein 4Type 3 innate lymphoid cellsMulti-organ inflammatory diseaseCTLA4-Ig monotherapyT-cell infiltratesInnate lymphoid cellsType V patientsT cell hyperproliferationReceptor-mediated activationT cell receptor-mediated activationILC3 frequenciesInterleukin-17A.Cell infiltrateCytokine concentrationsHistologic featuresInterleukin-22CTLA4 haploinsufficiencyClinical phenotypeB7 ligandsHeterozygous microdeletionReceptor CD28CD28