2014
Individual exome analysis in diagnosis and management of paediatric liver failure of indeterminate aetiology
Vilarinho S, Choi M, Jain D, Malhotra A, Kulkarni S, Pashankar D, Phatak U, Patel M, Bale A, Mane S, Lifton RP, Mistry PK. Individual exome analysis in diagnosis and management of paediatric liver failure of indeterminate aetiology. Journal Of Hepatology 2014, 61: 1056-1063. PMID: 25016221, PMCID: PMC4203706, DOI: 10.1016/j.jhep.2014.06.038.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceBase SequenceCarboxylic Ester HydrolasesChildCholestasisDNA Mutational AnalysisEnd Stage Liver DiseaseExomeFatal OutcomeFemaleGenes, RecessiveHepatolenticular DegenerationHeterozygoteHomozygoteHumansInfant, NewbornLiver FailureLiver Failure, AcuteMaleMembrane ProteinsMitochondrial ProteinsMolecular Sequence DataPedigreeReceptor, Notch2RNA Splice SitesSequence Homology, Amino AcidConceptsFatal acute liver failureWhole-exome sequencingAdvanced liver diseaseAcute liver failureIndeterminate etiologyYear old femaleLiver failureLiver diseaseMetabolic liver diseasePatient 3Treatment optionsPhenotypic spectrumPediatric liver failureDecompensated liver cirrhosisManagement of childrenOptimal treatment optionsAge 3 monthsNovel inborn errorLiver transplantAtypical presentationLiver cirrhosisHepatocerebral mitochondrial DNA depletion syndromePatient 1Patient 2Unknown etiology
2011
Pediatric Liver Transplantation for Inherited Metabolic Liver Disease: A Single-Center Experience
Rosencrantz R, Cimsit B, Seashore M, Arvelakis A, Kulkarni S, Ghiroli M, Emre S. Pediatric Liver Transplantation for Inherited Metabolic Liver Disease: A Single-Center Experience. Transplantation Proceedings 2011, 43: 896-900. PMID: 21486623, DOI: 10.1016/j.transproceed.2011.02.035.Peer-Reviewed Original ResearchConceptsMetabolic liver diseaseLiver diseaseMS patientsMetabolic diseasesLiver transplantLiver transplantationStatus 1Pediatric liver transplant recipientsPELD/MELD scoreM groupHeterozygote parentsNeurologic motor functionAcute cellular rejectionDonor liver transplantLiver transplant recipientsDetectable EBV DNAPediatric liver transplantationSingle-center experiencePatients' overall survivalPatient survival outcomesMajority of childrenGenetic liver diseasesCellular rejectionCMV viremiaExcellent allograft
2006
Ethics in Liver Transplantation
Kulkarni S, Cronin D. Ethics in Liver Transplantation. Seminars In Liver Disease 2006, 26: 234-238. PMID: 16850372, DOI: 10.1055/s-2006-947299.Peer-Reviewed Original ResearchConceptsEnd-stage liver diseaseDeceased donor liversLiver transplantationLiver diseaseManagement of comorbiditiesDeceased donor kidneysGraft survivalPreferred therapyLifesaving therapyCurrent allocation systemSurgical techniqueTransplantationPatientsLiverTherapyDiseaseInadequate supplyDeficiencyComorbiditiesImmunosuppressionMELDKidneyMortalitySuch deficienciesSpectacular improvement
2003
The sickest first? Disparities with model for end‐stage liver disease‐based organ allocation: One region's experience
Schaffer RL, Kulkarni S, Harper A, Millis JM, Cronin DC. The sickest first? Disparities with model for end‐stage liver disease‐based organ allocation: One region's experience. Liver Transplantation 2003, 9: 1211-1215. PMID: 14586883, DOI: 10.1053/jlts.2003.50192.Peer-Reviewed Original ResearchConceptsCadaver liversMELD scoreHepatocellular carcinomaOrgan allocationRegion patientsEnd-stage liver diseaseEquitable organ distributionMean MELD scoreMedian MELD scoreHigh MELD scoreLiver transplant programNumber of transplantationsOrgan Sharing regionsLiver recipientsPretransplantation mortalityMELD exceptionsLiver diseaseSingle centerUnited NetworkTransplant programsWaiting listTransplantationEvidence-based systemOrgan procurementTransplantation Network