Dual role of reactive oxygen species in autophagy and apoptosis induced by compound PN in prostate cancer cells
Choi H, Kim K, Park K, Kim S, Park S, Yu S, Kim Y, Kim D, Chung K, Ahn S. Dual role of reactive oxygen species in autophagy and apoptosis induced by compound PN in prostate cancer cells. Molecular & Cellular Toxicology 2020, 17: 41-50. DOI: 10.1007/s13273-020-00107-4.Peer-Reviewed Original ResearchMitochondrial reactive oxygen speciesReactive oxygen speciesCell deathMolecular mechanismsProstate cancer cellsPC-3 cellsCell survivalAnti-cancer activityROS productionApoptotic cell deathCancer cellsOxygen speciesROS-dependent mannerInduction of apoptosisProstate cancer PC-3 cellsHuman prostate cancer cellsAcceleration of apoptosisCancer PC-3 cellsInhibition of autophagyProduction of intracellularIntracellular ROS scavengerProstate cancer treatmentExpression of apoptosisAutophagy inductionWestern blot analysis