A Systematic Review and Meta-Analysis of Studies Evaluating the Effect of Medication Treatment for Opioid Use Disorder on Infectious Disease Outcomes
McNamara KF, Biondi BE, Hernández-Ramírez RU, Taweh N, Grimshaw AA, Springer SA. A Systematic Review and Meta-Analysis of Studies Evaluating the Effect of Medication Treatment for Opioid Use Disorder on Infectious Disease Outcomes. Open Forum Infectious Diseases 2021, 8: ofab289. PMID: 34430670, PMCID: PMC8378589, DOI: 10.1093/ofid/ofab289.Peer-Reviewed Original ResearchOpioid use disorderHepatitis C virusInfectious disease outcomesViral suppressionUse disordersVirologic responseDisease outcomeHuman immunodeficiency virus (HIV) viral suppressionNew hepatitis B virus (HBV) infectionsHepatitis B virus infectionGreater ART adherenceTreatment of OUDB virus infectionHIV viral suppressionAntiretroviral therapy adherenceImpact of medicationHCV reinfectionART adherenceMedication treatmentTherapy adherenceHIV treatmentInfectious disease epidemicsC virusOpioid epidemicTreatment outcomesDesign and methods of a multi-site randomized controlled trial of an integrated care model of long-acting injectable buprenorphine with infectious disease treatment among persons hospitalized with infections and opioid use disorder
Seval N, Frank CA, Litwin AH, Roth P, Schade MA, Pavlicova M, Levin FR, Brady KT, Nunes EV, Springer SA. Design and methods of a multi-site randomized controlled trial of an integrated care model of long-acting injectable buprenorphine with infectious disease treatment among persons hospitalized with infections and opioid use disorder. Contemporary Clinical Trials 2021, 105: 106394. PMID: 33838307, PMCID: PMC8172465, DOI: 10.1016/j.cct.2021.106394.Peer-Reviewed Original ResearchConceptsOpioid use disorderInfectious disease treatmentUse disordersCo-occurring opioid use disorderTreatment of OUDLife-threatening infectious diseaseSubstantial healthcare utilizationProportion of patientsInfectious disease specialistsInjection drug usePrimary outcome measureIntegrated care modelDisease treatmentMulti-site trialInjectable buprenorphineOpioid useSecondary outcomesHealthcare utilizationInfection morbidityDisease specialistsMedication treatmentSerious infectionsMonthly formulationDrug overdoseID specialists