2021
Is Aortic Z-score an Appropriate Index of Beneficial Drug Effect in Clinical Trials in Aortic Aneurysm Disease?
Elkinany S, Weismann C, Curtis A, Smith T, Zafar MA, Breen T, Li Y, Tranquilli M, Rizzo JA, Mukherjee SK, Ziganshin BA, Elefteriades JA. Is Aortic Z-score an Appropriate Index of Beneficial Drug Effect in Clinical Trials in Aortic Aneurysm Disease? The American Journal Of Cardiology 2021, 143: 145-153. PMID: 33352210, DOI: 10.1016/j.amjcard.2020.12.025.Peer-Reviewed Original ResearchConceptsBody mass indexAortic Z-scoresZ-score decreaseBeneficial drug effectsZ-scoreMarfan patientsClinical trialsAneurysm diseaseDrug effectsChild's ageEcho examAortic dilation rateDecreased Z-scoreConnective tissue diseaseBody surface areaEffects of medicationAortic aneurysm diseaseClinical drug trialsMass indexTissue diseaseAortic diseaseAneurysmal pathologyDrug trialsInvestigational drugsSpontaneous decrease
2018
Chapter 22 Current Status of Medical Therapy of Thoracic Aortic Aneurysm and Dissection
Percy A, Mukherjee S, Ziganshin B, Elefteriades J. Chapter 22 Current Status of Medical Therapy of Thoracic Aortic Aneurysm and Dissection. 2018, 235-249. DOI: 10.1016/b978-0-12-809979-7.00022-5.Peer-Reviewed Original ResearchThoracic aortic aneurysmAortic aneurysmMost thoracic aortic aneurysmsAngiotensin receptor blockersClasses of medicationsAortic aneurysm developmentRelevant clinical endpointsAortic aneurysm expansionAsymptomatic patientsLifestyle modificationReceptor blockersMedical therapySurgical repairAortic catastropheClinical evidencePathophysiologic pathwaysSurgical interventionPathophysiologic basisTreatment modalitiesAneurysm expansionClinical endpointsClinical trialsCurrent guidelinesAneurysm formationClinical studies
2013
Do β-Blockers Really Work for Prevention of Aortic Aneurysms?
Chun AS, Elefteriades JA, Mukherjee SK. Do β-Blockers Really Work for Prevention of Aortic Aneurysms? Aorta 2013, 01: 45-51. PMID: 26798671, PMCID: PMC4682697, DOI: 10.12945/j.aorta.2013.13.002.Peer-Reviewed Original ResearchΒ-blockade therapyΒ-blocker treatmentAortic aneurysmMarfan syndromeClinical trialsMulticenter clinical trialSeparate clinical trialsScientific evidenceAdrenergic-blocking drugsAortic aneurysm growthAortic diseaseConventional therapyΒ-blockersGeneral populationPatientsAneurysmsSyndromeAneurysm growthTherapyTrialsTreatmentLiterature reviewDiseaseProgressionPrevention