2023
Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University
Wu J, Zafar M, Liu Y, Chen J, Li Y, Ziganshin B, Ellauzi H, Mukherjee S, Rizzo J, Elefteriades J. Fate of the unoperated ascending thoracic aortic aneurysm: three-decade experience from the Aortic Institute at Yale University. European Heart Journal 2023, 44: 4579-4588. PMID: 36994934, DOI: 10.1093/eurheartj/ehad148.Peer-Reviewed Original ResearchConceptsAdverse aortic eventsThoracic aortic aneurysmAortic sizeAortic aneurysmCox regressionAortic growthRisk factorsSignificant independent risk factorsMultivariable Cox regressionIndependent risk factorCohort of patientsUnivariable Cox regressionSignificant protective factorAortic deathATAA patientsAortic eventsPrimary endpointSurgical interventionThree-decade experienceNatural historyYearly riskProtective factorsAneurysmsPatientsIntervention criteria
2022
A machine learning approach for predicting complications in descending and thoracoabdominal aortic aneurysms
Ostberg NP, Zafar MA, Mukherjee SK, Ziganshin BA, Elefteriades JA. A machine learning approach for predicting complications in descending and thoracoabdominal aortic aneurysms. Journal Of Thoracic And Cardiovascular Surgery 2022, 166: 1011-1020.e3. PMID: 35120761, DOI: 10.1016/j.jtcvs.2021.12.045.Peer-Reviewed Original ResearchConceptsType B dissectionThoracoabdominal aortic aneurysmsB dissectionCause mortalityAortic aneurysmReceiver operator curveAortic diameterOperator curveInitial patient encounterOccurrence of dissectionSurgical intervention criteriaMean followPatient sexMyocardial infarctionPatient encountersRetrospective dataEnd pointPatientsAneurysmsDissectionMortalityRisk predictionComplicationsIntervention criteriaRupturePhenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm
Prendergast A, Ziganshin BA, Papanikolaou D, Zafar MA, Nicoli S, Mukherjee S, Elefteriades JA. Phenotyping Zebrafish Mutant Models to Assess Candidate Genes Associated with Aortic Aneurysm. Genes 2022, 13: 123. PMID: 35052463, PMCID: PMC8775119, DOI: 10.3390/genes13010123.Peer-Reviewed Original ResearchConceptsAortic aneurysmSkeletal abnormalitiesThoracic aortic aneurysmWhole-exome sequencingDirect microscopic assessmentSilico genetic analysisVisualized abnormalitiesTAA patientsClinical managementGeneral populationClinical practiceRoutine assessmentClinical testingCell countEvidence-based decisionsUnknown significanceUncertain significanceExperimental modelPilot studyExome sequencingAbnormalitiesMicroscopic assessmentPatientsPositive controlAneurysms
2020
Increased Virulence of Descending Thoracic and Thoracoabdominal Aortic Aneurysms in Women
Chen JF, Zafar MA, Wu J, Li Y, Rizzo JA, Papanikolaou D, Kalogerakos P, Abdelbaky M, Ellauzi H, Rohde S, Vinholo TF, Charilaou P, Buntin J, Mukherjee SK, Ziganshin BA, Elefteriades JA. Increased Virulence of Descending Thoracic and Thoracoabdominal Aortic Aneurysms in Women. The Annals Of Thoracic Surgery 2020, 112: 45-52. PMID: 33075319, DOI: 10.1016/j.athoracsur.2020.08.026.Peer-Reviewed Original ResearchConceptsThoracoabdominal aortic aneurysmsAortic deathFatal complicationAortic sizeAortic aneurysmFaster aneurysm growthMean aortic diameterComplication rateComposite endpointAortic diameterSurgical interventionCurrent guidelinesAneurysm sizeSex considerationsNatural historyAneurysm growthThoracicWomenDissectionYearly rateComplicationsDeathAneurysmsHigh rateSex differences
2013
Medical Treatment for Thoracic Aortic Aneurysm – Much More Work To Be Done
Chun AS, Elefteriades JA, Mukherjee SK. Medical Treatment for Thoracic Aortic Aneurysm – Much More Work To Be Done. Progress In Cardiovascular Diseases 2013, 56: 103-108. PMID: 23993243, DOI: 10.1016/j.pcad.2013.05.008.Peer-Reviewed Original ResearchConceptsReceptor blockersAortic diseaseAortic aneurysmMedical treatmentBeta-adrenergic receptor blockersAngiotensin receptor blockersAortic aneurysm repairForms of pharmacotherapyThoracic aortic diseaseThoracic aortic aneurysmMatrix metalloproteinase inhibitorsAortic surgeryAortic expansionAneurysm repairAortic ruptureMedical therapySurgical repairSurgical interventionAortic riskAortic valveGuideline criteriaMaximal diameterMetalloproteinase inhibitorsFuture riskAneurysmsDo β-Blockers Really Work for Prevention of Aortic Aneurysms?
Chun AS, Elefteriades JA, Mukherjee SK. Do β-Blockers Really Work for Prevention of Aortic Aneurysms? Aorta 2013, 01: 45-51. PMID: 26798671, PMCID: PMC4682697, DOI: 10.12945/j.aorta.2013.13.002.Peer-Reviewed Original ResearchΒ-blockade therapyΒ-blocker treatmentAortic aneurysmMarfan syndromeClinical trialsMulticenter clinical trialSeparate clinical trialsScientific evidenceAdrenergic-blocking drugsAortic aneurysm growthAortic diseaseConventional therapyΒ-blockersGeneral populationPatientsAneurysmsSyndromeAneurysm growthTherapyTrialsTreatmentLiterature reviewDiseaseProgressionPrevention
2012
Carotid Intima-Media Thickness Provides Evidence that Ascending Aortic Aneurysm Protects against Systemic Atherosclerosis
Hung A, Zafar M, Mukherjee S, Tranquilli M, Scoutt LM, Elefteriades JA. Carotid Intima-Media Thickness Provides Evidence that Ascending Aortic Aneurysm Protects against Systemic Atherosclerosis. Cardiology 2012, 123: 71-77. PMID: 23006774, DOI: 10.1159/000341234.Peer-Reviewed Original ResearchConceptsIntima-media thicknessCarotid intima-media thicknessAortic aneurysmCalcium scoreAortic calcium scoreAverage intima-media thicknessAortic aneurysm patientsCarotid IMT valuesDegree of atherosclerosisPositive family historyAortic aneurysm developmentDevelopment of atherosclerosisCommon carotid arterySystemic atherosclerosisAneurysm patientsIMT valuesMale genderRisk factorsCarotid arteryFamily historyMultiple linear regression analysisAtherosclerosisEarly markerAneurysm developmentAneurysms