2023
A0964 Four-year follow-up of MRI-guided Transurethral Ultrasound Ablation (TULSA) in men with localized prostate cancer
Klotz L, Chin J, Futterer J, Hatiboglu G, Pavlovich C, Koch M, Penson D, Relle J, Raman S, Lotan Y, Serrallach M, Heidenreich A, Oto A, Sedelaar J, Tirkes T, Arora S, Macura K, Costa D, Pantuck A, Bomers J, Bonekamp D, Persigehl T, Clarke G, Eggener S. A0964 Four-year follow-up of MRI-guided Transurethral Ultrasound Ablation (TULSA) in men with localized prostate cancer. European Urology 2023, 83: s1381-s1382. DOI: 10.1016/s0302-2838(23)01004-7.Peer-Reviewed Original Research
2021
MR-Guided High-Intensity Directional Ultrasound Ablation of Prostate Cancer
Galgano SJ, Planz VB, Arora S, Rais-Bahrami S. MR-Guided High-Intensity Directional Ultrasound Ablation of Prostate Cancer. Current Urology Reports 2021, 22: 3. PMID: 33403460, DOI: 10.1007/s11934-020-01020-y.Peer-Reviewed Original ResearchConceptsTreatment modalitiesProstate cancerFocal therapyFavorable side effect profileLong-term oncologic outcomesSide effect profileMR-Guided HighNovel treatment modalitiesPromising early resultsProstate cancer diagnosisOncologic outcomesDefinitive treatmentUrinary sphincterNeurovascular bundleRadical prostatectomyActive surveillanceRadiation therapyFocal ablationHeterogeneous diseaseProstate glandReviewThe goalTherapyUltrasound ablationCancer diagnosisProstate MRI
2020
Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Cancer.
Klotz L, Pavlovich CP, Chin J, Hatiboglu G, Koch M, Penson D, Raman S, Oto A, Fütterer J, Serrallach M, Relle J, Lotan Y, Heidenreich A, Bonekamp D, Haider M, Tirkes T, Arora S, Macura KJ, Costa DN, Persigehl T, Pantuck AJ, Bomers J, Burtnyk M, Staruch R, Eggener S. Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Cancer. Journal Of Urology 2020, 205: 769-779. PMID: 33021440, DOI: 10.1097/ju.0000000000001362.Peer-Reviewed Original ResearchConceptsGrade Group 2 diseaseProstate-specific antigen reductionGrade group 2Whole gland ablationTransurethral ultrasound ablationAntigen reductionMagnetic resonance imagingProstate cancerGroup 2Gland ablationMagnetic resonance imaging-guided transurethral ultrasound ablationGrade 3 adverse eventsResonance imagingTarget volumeEvidence of cancerUltrasound ablationIntermediate-risk diseaseRisk prostate cancerProspective multicenter trialMedian prostate volumeLocalized prostate cancerMedian treatment delivery timeTreatment delivery timeMagnetic resonancePrimary endpoint883 Pivotal trial of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Two-year follow-up
Klotz L, Chin J, Hatiboglu G, Koch M, Penson D, Pavlovich C, Raman S, Oto A, Fütterer J, Relle J, Lotan Y, Heidenreich A, Serrallach M, Haider M, Bonekamp D, Tirkes T, Arora S, Pantuck A, Zagaja G, Sedelaar M, Macura K, Costa D, Persigehl T, Eggener S. 883 Pivotal trial of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Two-year follow-up. European Urology Open Science 2020, 19: e1338-e1339. DOI: 10.1016/s2666-1683(20)33481-9.Peer-Reviewed Original ResearchMagnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial
Sundaram KM, Staruch R, Burtnyk M, Lane JS, Penson DF, Arora SS. Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial. Journal Of Vascular And Interventional Radiology 2020, 31: 740-746.e4. PMID: 32307311, DOI: 10.1016/j.jvir.2019.12.802.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAgedAged, 80 and overHumansMagnetic Resonance Imaging, InterventionalMaleMiddle AgedNeoplasm GradingNeoplasm StagingOntarioPreliminary DataProspective StudiesProstatic NeoplasmsTime FactorsTransurethral Resection of ProstateTreatment OutcomeUltrasonic Surgical ProceduresConceptsTransurethral ultrasound ablationProstate cancerMagnetic resonance imaging-guided transurethral ultrasound ablationIntermediate-risk prostate cancerUltrasound ablationIntermediate-risk diseaseSingle-center experienceGastrointestinal side effectsLocalized prostate cancerArm clinical trialMagnetic resonance imagingHistologic benefitPostprocedural changesPrimary endpointSingle centerClinical trialsMulti-CenterSide effectsPreliminary experienceResonance imagingPatientsProstate treatmentCancerAblationBiopsy3:45 PM Abstract No. 341 Pivotal study of magnetic resonance imaging–guided transurethral ultrasound ablation in men with localized prostate cancer: 12-month clinical and imaging outcomes
Raman S, Futterer J, Oto A, Arora S, Tirkes T, Macura K, Bonekamp D, Haider M, Cool D, Nandalur K, Nicolau C, Costa D, Persigehl T, Purysko A, Staruch R, Burtnyk M, Chin J, Klotz L, Eggener S. 3:45 PM Abstract No. 341 Pivotal study of magnetic resonance imaging–guided transurethral ultrasound ablation in men with localized prostate cancer: 12-month clinical and imaging outcomes. Journal Of Vascular And Interventional Radiology 2020, 31: s154-s155. DOI: 10.1016/j.jvir.2019.12.398.Peer-Reviewed Original Research
2019
472 Pivotal study of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Preliminary results
Klotz L, Hatiboglu G, Fütterer J, Persigehl T, Serrallach M, Koch M, Pavlovich C, Lotan Y, Raman S, Relle J, Zagaja G, Haider M, Arora S, Staruch R, Burtnyk M, Costa D, Oto A, Tirkes T, Sedelaar J, Bonekamp D, Heidenreich A, Penson D, Chin J, Eggener S. 472 Pivotal study of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Preliminary results. European Urology Open Science 2019, 18: e620-e621. DOI: 10.1016/s1569-9056(19)30459-2.Peer-Reviewed Original Research
2018
LBA20 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION (TULSA) IN PATIENTS WITH LOCALIZED PROSTATE CANCER: PRELIMINARY RESULTS OF TACT PIVOTAL STUDY
Klotz L, Penson D, Chin J, Pavlovich C, Relle J, Koch M, Hatiboglu G, Oto A, Futterer J, Raman S, Lotan Y, Persigehl T, Heidenreich A, Suarez J, Staruch R, Burtnyk M, Pantuck A, Sedelaar J, Arora S, Zagaja G, Tirkes T, Macura K, Bonekamp D, Haider M, Eggener S. LBA20 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION (TULSA) IN PATIENTS WITH LOCALIZED PROSTATE CANCER: PRELIMINARY RESULTS OF TACT PIVOTAL STUDY. Journal Of Urology 2018, 199: e1077-e1078. DOI: 10.1016/j.juro.2018.03.091.Peer-Reviewed Original Research
2017
Therapeutic Ultrasound and Prostate Cancer
Sundaram KM, Chang SS, Penson DF, Arora S. Therapeutic Ultrasound and Prostate Cancer. Seminars In Interventional Radiology 2017, 34: 187-200. PMID: 28579687, PMCID: PMC5453783, DOI: 10.1055/s-0037-1602710.Peer-Reviewed Original ResearchProstate cancerIntermediate-risk prostate cancerRisk prostate cancerAdverse event ratesInvasive alternative treatmentExternal beam radiotherapyDefinitive therapyAdverse eventsUrinary incontinenceClinical efficacyErectile dysfunctionRadical prostatectomyClinical trialsFocal therapyAlternative treatmentFDA approvalEvent ratesUltrasound ablationMRI guidanceTherapeutic ultrasoundUltrasound approachTherapyHIFU deviceCancerUltrasound