2023
A0964 Four-year follow-up of MRI-guided Transurethral Ultrasound Ablation (TULSA) in men with localized prostate cancer
Klotz L, Chin J, Futterer J, Hatiboglu G, Pavlovich C, Koch M, Penson D, Relle J, Raman S, Lotan Y, Serrallach M, Heidenreich A, Oto A, Sedelaar J, Tirkes T, Arora S, Macura K, Costa D, Pantuck A, Bomers J, Bonekamp D, Persigehl T, Clarke G, Eggener S. A0964 Four-year follow-up of MRI-guided Transurethral Ultrasound Ablation (TULSA) in men with localized prostate cancer. European Urology 2023, 83: s1381-s1382. DOI: 10.1016/s0302-2838(23)01004-7.Peer-Reviewed Original Research
2022
Real-Time MRI-Guided Prostate Interventions
Masoom SN, Sundaram KM, Ghanouni P, Fütterer J, Oto A, Ayyagari R, Sprenkle P, Weinreb J, Arora S. Real-Time MRI-Guided Prostate Interventions. Cancers 2022, 14: 1860. PMID: 35454773, PMCID: PMC9030365, DOI: 10.3390/cancers14081860.Peer-Reviewed Original Research
2021
MP46-03 PIVOTAL TRIAL OF MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN MEN WITH LOCALIZED PROSTATE CANCER: THREE-YEAR FOLLOW-UP
Klotz L, Pavlovich C, Chin J, Hatiboglu G, Koch M, Penson D, Raman S, Oto A, Fütterer J, Serrallach M, Relle J, Lotan Y, Heidenreich A, Bonekamp D, Haider M, Sedelaar J, Tirkes T, Arora S, Macura K, Costa D, Pantuck A, Bomers J, Clarke G, Staruch R, Eggener S. MP46-03 PIVOTAL TRIAL OF MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN MEN WITH LOCALIZED PROSTATE CANCER: THREE-YEAR FOLLOW-UP. Journal Of Urology 2021, 206: e814-e814. DOI: 10.1097/ju.0000000000002067.03.Peer-Reviewed Original ResearchThe impact and collateral damage of COVID-19 on prostate MRI and guided biopsy operations: Society of Abdominal Radiology Prostate Cancer Disease-Focused Panel survey analysis
Surasi DSS, Wang X, Bathala TK, Hwang H, Arora S, Westphalen AC, Chang SD, Turkbey B. The impact and collateral damage of COVID-19 on prostate MRI and guided biopsy operations: Society of Abdominal Radiology Prostate Cancer Disease-Focused Panel survey analysis. Abdominal Radiology 2021, 46: 4362-4369. PMID: 33904992, PMCID: PMC8077193, DOI: 10.1007/s00261-021-03087-8.Peer-Reviewed Original ResearchConceptsBowel preparationMedian numberProstate MRICoronavirus disease 2019 (COVID-19) pandemicCOVID-19Disease 2019 pandemicCOVID-19 pandemicHealth care systemComplete responseMedical oncologyProstate biopsyClinic schedulesProstate cancerMRI studiesLockdown periodCare systemCollateral damageRadiation oncologyClinical departmentsPanel survey analysisMRIBiopsyRadiology departmentOncologyDescriptive statisticsMR-Guided High-Intensity Directional Ultrasound Ablation of Prostate Cancer
Galgano SJ, Planz VB, Arora S, Rais-Bahrami S. MR-Guided High-Intensity Directional Ultrasound Ablation of Prostate Cancer. Current Urology Reports 2021, 22: 3. PMID: 33403460, DOI: 10.1007/s11934-020-01020-y.Peer-Reviewed Original ResearchConceptsTreatment modalitiesProstate cancerFocal therapyFavorable side effect profileLong-term oncologic outcomesSide effect profileMR-Guided HighNovel treatment modalitiesPromising early resultsProstate cancer diagnosisOncologic outcomesDefinitive treatmentUrinary sphincterNeurovascular bundleRadical prostatectomyActive surveillanceRadiation therapyFocal ablationHeterogeneous diseaseProstate glandReviewThe goalTherapyUltrasound ablationCancer diagnosisProstate MRI
2020
Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Cancer.
Klotz L, Pavlovich CP, Chin J, Hatiboglu G, Koch M, Penson D, Raman S, Oto A, Fütterer J, Serrallach M, Relle J, Lotan Y, Heidenreich A, Bonekamp D, Haider M, Tirkes T, Arora S, Macura KJ, Costa DN, Persigehl T, Pantuck AJ, Bomers J, Burtnyk M, Staruch R, Eggener S. Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Cancer. Journal Of Urology 2020, 205: 769-779. PMID: 33021440, DOI: 10.1097/ju.0000000000001362.Peer-Reviewed Original ResearchConceptsGrade Group 2 diseaseProstate-specific antigen reductionGrade group 2Whole gland ablationTransurethral ultrasound ablationAntigen reductionMagnetic resonance imagingProstate cancerGroup 2Gland ablationMagnetic resonance imaging-guided transurethral ultrasound ablationGrade 3 adverse eventsResonance imagingTarget volumeEvidence of cancerUltrasound ablationIntermediate-risk diseaseRisk prostate cancerProspective multicenter trialMedian prostate volumeLocalized prostate cancerMedian treatment delivery timeTreatment delivery timeMagnetic resonancePrimary endpoint883 Pivotal trial of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Two-year follow-up
Klotz L, Chin J, Hatiboglu G, Koch M, Penson D, Pavlovich C, Raman S, Oto A, Fütterer J, Relle J, Lotan Y, Heidenreich A, Serrallach M, Haider M, Bonekamp D, Tirkes T, Arora S, Pantuck A, Zagaja G, Sedelaar M, Macura K, Costa D, Persigehl T, Eggener S. 883 Pivotal trial of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Two-year follow-up. European Urology Open Science 2020, 19: e1338-e1339. DOI: 10.1016/s2666-1683(20)33481-9.Peer-Reviewed Original ResearchVariability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel
Westphalen AC, McCulloch CE, Anaokar JM, Arora S, Barashi NS, Barentsz JO, Bathala TK, Bittencourt LK, Booker MT, Braxton VG, Carroll PR, Casalino DD, Chang SD, Coakley FV, Dhatt R, Eberhardt SC, Foster BR, Froemming AT, Fütterer JJ, Ganeshan DM, Gertner MR, Mankowski Gettle L, Ghai S, Gupta RT, Hahn ME, Houshyar R, Kim C, Kim CK, Lall C, Margolis DJA, McRae SE, Oto A, Parsons RB, Patel NU, Pinto PA, Polascik TJ, Spilseth B, Starcevich JB, Tammisetti VS, Taneja SS, Turkbey B, Verma S, Ward JF, Warlick CA, Weinberger AR, Yu J, Zagoria RJ, Rosenkrantz AB. Variability of the Positive Predictive Value of PI-RADS for Prostate MRI across 26 Centers: Experience of the Society of Abdominal Radiology Prostate Cancer Disease-focused Panel. Radiology 2020, 296: 76-84. PMID: 32315265, PMCID: PMC7373346, DOI: 10.1148/radiol.2020190646.Peer-Reviewed Original ResearchConceptsPositive predictive valuePI-RADS scoreProstate cancerPI-RADSGleason scorePredictive valueRetrospective cross-sectional studyHigh-grade prostate cancerObserved positive predictive valueOverall positive predictive valueUntreated prostate cancerProstate MRIInterquartile rangeSignificant prostate cancerProstate Imaging ReportingCross-sectional studyMixed-model logistic regressionProstate cancer diseaseReporting Data SystemMRI lesionsBiopsy resultsActive surveillanceClinical careMRI scansImaging ReportingMagnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial
Sundaram KM, Staruch R, Burtnyk M, Lane JS, Penson DF, Arora SS. Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer: Preliminary Experience from a Single Center in a Prospective, Multi-Center, Single-Arm Clinical Trial. Journal Of Vascular And Interventional Radiology 2020, 31: 740-746.e4. PMID: 32307311, DOI: 10.1016/j.jvir.2019.12.802.Peer-Reviewed Original ResearchMeSH KeywordsAblation TechniquesAgedAged, 80 and overHumansMagnetic Resonance Imaging, InterventionalMaleMiddle AgedNeoplasm GradingNeoplasm StagingOntarioPreliminary DataProspective StudiesProstatic NeoplasmsTime FactorsTransurethral Resection of ProstateTreatment OutcomeUltrasonic Surgical ProceduresConceptsTransurethral ultrasound ablationProstate cancerMagnetic resonance imaging-guided transurethral ultrasound ablationIntermediate-risk prostate cancerUltrasound ablationIntermediate-risk diseaseSingle-center experienceGastrointestinal side effectsLocalized prostate cancerArm clinical trialMagnetic resonance imagingHistologic benefitPostprocedural changesPrimary endpointSingle centerClinical trialsMulti-CenterSide effectsPreliminary experienceResonance imagingPatientsProstate treatmentCancerAblationBiopsyPD17-02 PIVOTAL TRIAL OF MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN MEN WITH LOCALIZED PROSTATE CANCER: TWO-YEAR FOLLOW-UP
Eggener* S, Koch M, Penson D, Pavlovich C, Chin J, Lotan Y, Raman S, Hatiboglu G, Oto A, Relle J, Fütterer J, Serrallach M, Heidenreich A, Haider M, Bonekamp D, Tirkes T, Arora S, Pantuck A, Zagaja G, Sedelaar M, Macura K, Costa D, Persigehl T, Purysko A, Klotz L. PD17-02 PIVOTAL TRIAL OF MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION IN MEN WITH LOCALIZED PROSTATE CANCER: TWO-YEAR FOLLOW-UP. Journal Of Urology 2020, 203 DOI: 10.1097/ju.0000000000000860.02.Peer-Reviewed Original Research3:45 PM Abstract No. 341 Pivotal study of magnetic resonance imaging–guided transurethral ultrasound ablation in men with localized prostate cancer: 12-month clinical and imaging outcomes
Raman S, Futterer J, Oto A, Arora S, Tirkes T, Macura K, Bonekamp D, Haider M, Cool D, Nandalur K, Nicolau C, Costa D, Persigehl T, Purysko A, Staruch R, Burtnyk M, Chin J, Klotz L, Eggener S. 3:45 PM Abstract No. 341 Pivotal study of magnetic resonance imaging–guided transurethral ultrasound ablation in men with localized prostate cancer: 12-month clinical and imaging outcomes. Journal Of Vascular And Interventional Radiology 2020, 31: s154-s155. DOI: 10.1016/j.jvir.2019.12.398.Peer-Reviewed Original Research
2019
472 Pivotal study of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Preliminary results
Klotz L, Hatiboglu G, Fütterer J, Persigehl T, Serrallach M, Koch M, Pavlovich C, Lotan Y, Raman S, Relle J, Zagaja G, Haider M, Arora S, Staruch R, Burtnyk M, Costa D, Oto A, Tirkes T, Sedelaar J, Bonekamp D, Heidenreich A, Penson D, Chin J, Eggener S. 472 Pivotal study of MRI-guided transurethral ultrasound ablation in men with localized prostate cancer: Preliminary results. European Urology Open Science 2019, 18: e620-e621. DOI: 10.1016/s1569-9056(19)30459-2.Peer-Reviewed Original Research
2018
LBA20 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION (TULSA) IN PATIENTS WITH LOCALIZED PROSTATE CANCER: PRELIMINARY RESULTS OF TACT PIVOTAL STUDY
Klotz L, Penson D, Chin J, Pavlovich C, Relle J, Koch M, Hatiboglu G, Oto A, Futterer J, Raman S, Lotan Y, Persigehl T, Heidenreich A, Suarez J, Staruch R, Burtnyk M, Pantuck A, Sedelaar J, Arora S, Zagaja G, Tirkes T, Macura K, Bonekamp D, Haider M, Eggener S. LBA20 MRI-GUIDED TRANSURETHRAL ULTRASOUND ABLATION (TULSA) IN PATIENTS WITH LOCALIZED PROSTATE CANCER: PRELIMINARY RESULTS OF TACT PIVOTAL STUDY. Journal Of Urology 2018, 199: e1077-e1078. DOI: 10.1016/j.juro.2018.03.091.Peer-Reviewed Original Research
2017
Therapeutic Ultrasound and Prostate Cancer
Sundaram KM, Chang SS, Penson DF, Arora S. Therapeutic Ultrasound and Prostate Cancer. Seminars In Interventional Radiology 2017, 34: 187-200. PMID: 28579687, PMCID: PMC5453783, DOI: 10.1055/s-0037-1602710.Peer-Reviewed Original ResearchProstate cancerIntermediate-risk prostate cancerRisk prostate cancerAdverse event ratesInvasive alternative treatmentExternal beam radiotherapyDefinitive therapyAdverse eventsUrinary incontinenceClinical efficacyErectile dysfunctionRadical prostatectomyClinical trialsFocal therapyAlternative treatmentFDA approvalEvent ratesUltrasound ablationMRI guidanceTherapeutic ultrasoundUltrasound approachTherapyHIFU deviceCancerUltrasound
2016
Magnetic resonance-ultrasound fusion prostate biopsy in the diagnosis of prostate cancer
Tyson MD, Arora SS, Scarpato KR, Barocas D. Magnetic resonance-ultrasound fusion prostate biopsy in the diagnosis of prostate cancer. Urologic Oncology Seminars And Original Investigations 2016, 34: 326-332. PMID: 27083114, PMCID: PMC4912896, DOI: 10.1016/j.urolonc.2016.03.005.Peer-Reviewed Original ResearchConceptsMultiparametric magnetic resonance imagingMR-US fusionProstate cancerMR-US fusion biopsyLow-risk cancersFusion prostate biopsyProstate needle biopsyBore MRI-guided biopsyMRI-guided biopsyMagnetic resonance imagingInsignificant diseaseFusion biopsyProstate biopsyNeedle biopsySuspicious lesionsTransrectal ultrasoundBiopsyBiopsy techniqueResonance imagingCancerDirect targetingRelevant diseasesProstateDiseaseDiagnosis