2022
International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators
Price RB, Kissel N, Baumeister A, Rohac R, Woody ML, Ballard ED, Zarate CA, Deakin W, Abdallah CG, Feder A, Charney DS, Grunebaum MF, Mann JJ, Mathew SJ, Gallagher B, McLoughlin DM, Murrough JW, Muthukumaraswamy S, McMillan R, Sumner R, Papakostas G, Fava M, Hock R, Phillips JL, Blier P, Shiroma P, Šóš P, Su TP, Chen MH, Tiger M, Lundberg J, Wilkinson ST, Wallace ML. International pooled patient-level meta-analysis of ketamine infusion for depression: In search of clinical moderators. Molecular Psychiatry 2022, 27: 5096-5112. PMID: 36071111, PMCID: PMC9763119, DOI: 10.1038/s41380-022-01757-7.Peer-Reviewed Original ResearchConceptsMontgomery-Åsberg Depression Rating ScaleIndividual patient-level dataRating ScalePatient-level featuresDepression Rating ScaleHamilton Rating ScalePatient-level dataPrecision medicine approachRelevant psychiatric diagnosisEligible trialsIntravenous ketamineAntidepressant medicationStudy entryKetamine infusionPrior medicationAntidepressant propertiesKetamine effectsControl armClinical moderatorsTreatment decisionsTreatment resistanceStudy-level moderatorsDepressive symptomsPersonalized prescriptionDepression severity
2021
United States national trends in prevalence of major depressive episode and co-occurring suicidal ideation and treatment resistance among adults
Voelker J, Kuvadia H, Cai Q, Wang K, Daly E, Pesa J, Connolly N, Sheehan J, Wilkinson S. United States national trends in prevalence of major depressive episode and co-occurring suicidal ideation and treatment resistance among adults. Journal Of Affective Disorders Reports 2021, 5: 100172. DOI: 10.1016/j.jadr.2021.100172.Peer-Reviewed Original ResearchMajor depressive episodeTreatment-resistant depressionPrevalence of SISuicidal ideationDepressive episodePast-year major depressive episodeUnited States national trendsRate of diagnosisNative Americans/Alaskan NativesDepression screeningClinical evaluationTreatment resistanceUS adultsRisk individualsPrevalence estimatesDrug useSociodemographic characteristicsSuicide planYearly prevalencePrevalenceYoung adultsAlaskan NativesSociodemographic groupsSelf-reported dataNational trends