Featured Publications
Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series
Shah SM, Odanovic N, Kunnirickal S, Feher A, Pfau SE, Spatz ES. Chest pain and coronary endothelial dysfunction after recovery from COVID‐19: A case series. Clinical Case Reports 2022, 10: e05612. PMID: 35425611, PMCID: PMC8991764, DOI: 10.1002/ccr3.5612.Peer-Reviewed Case Reports and Technical NotesThe Challenge of Myocardial Bridging
Shah S, Quesada O, Henry T. The Challenge of Myocardial Bridging. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100545. PMID: 39129805, PMCID: PMC11308591, DOI: 10.1016/j.jscai.2022.100545.Commentaries, Editorials and LettersComprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review
Samuels B, Shah S, Widmer R, Kobayashi Y, Miner S, Taqueti V, Jeremias A, Albadri A, Blair J, Kearney K, Wei J, Park K, El-Farra A, Holoshitz N, Janaszek K, Kesarwani M, Lerman A, Prasad M, Quesada O, Reynolds H, Savage M, Smilowitz N, Sutton N, Sweeny J, Toleva O, Henry T, Moses J, Fearon W, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 1—Definition, Patient Population, and Diagnosis JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1245-1263. PMID: 37704315, DOI: 10.1016/j.jacc.2023.06.043.Peer-Reviewed Original ResearchConceptsCoronary function testingMyocardial bridgingCoronary angiographyMultiple medical providersNonobstructive coronary arteriesCoronary microvascular dysfunctionDiagnostic coronary angiographyIschemic heart diseaseInvasive coronary angiographyCoronary flow reserveCardiac catheterization laboratoryCoronary abnormalitiesCoronary vasospasmEpicardial spasmMicrocirculatory resistanceEndothelial dysfunctionMicrovascular dysfunctionHemodynamic assessmentProvocative testingCoronary arteryFunction testingPatient populationHeart diseaseJACC StateFlow reserveComprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review
Smilowitz N, Prasad M, Widmer R, Toleva O, Quesada O, Sutton N, Lerman A, Reynolds H, Kesarwani M, Savage M, Sweeny J, Janaszek K, El-Farra A, Holoshitz N, Park K, Albadri A, Blair J, Jeremias A, Kearney K, Kobayashi Y, Miner S, Samuels B, Shah S, Taqueti V, Wei J, Fearon W, Moses J, Henry T, Tremmel J, Network M. Comprehensive Management of ANOCA, Part 2—Program Development, Treatment, and Research Initiatives JACC State-of-the-Art Review. Journal Of The American College Of Cardiology 2023, 82: 1264-1279. PMID: 37704316, DOI: 10.1016/j.jacc.2023.06.044.Peer-Reviewed Original ResearchConceptsCoronary function testingFunction testingFuture large-scale clinical trialsLarge-scale clinical trialsNonobstructive coronary arteriesStandardized symptom assessmentMultidisciplinary care teamTreatment of anginaIndividual patient needsQuality of lifeAngina burdenTherapeutic optionsCoronary arterySymptom assessmentClinical trialsCare teamTitrate therapyPatient needsANOCAComprehensive managementTreatmentComprehensive programAnginaPatientsArteryMultimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report
Shah T, Shah N, Baldassarre L, Freed L, Mojibian H, Shah S. Multimodality Evaluation of Spontaneous Coronary Artery Dissection in a Patient With Connective Tissue Disease: A Case Report. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 101125. PMID: 39129904, PMCID: PMC11308843, DOI: 10.1016/j.jscai.2023.101125.Peer-Reviewed Case Reports and Technical NotesIllness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study.
Tseng L, Göç N, Schwann A, Cherlin E, Kunnirickal S, Odanovic N, Curry L, Shah S, Spatz E. Illness Perception and the Impact of a Definitive Diagnosis on Women With Ischemia and No Obstructive Coronary Artery Disease: A Qualitative Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: 521-529. PMID: 37476997, DOI: 10.1161/circoutcomes.122.009834.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseCoronary function testingCoronary artery diseaseInvasive coronary angiographyArtery diseaseCoronary angiographyFunction testingDefinitive diagnosisYale-New Haven HospitalNon-Hispanic blacksMore patient-centered careNew Haven HospitalPatient-centered careStructured telephone interviewQuality of lifeHealth care experiencesNon-Hispanic whitesGroup of womenCoronary functionIllness perceptionsMean ageINOCAUncertain causeMultidisciplinary teamPatient careDetermining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamié D, Grubman D, Henrici K, Matmusaeva E, Latif N, Cigarroa N, Lansky A. Determining the Cause of Coronary Vasomotor Disorders in Patients With Ischemia and Nonobstructive Coronary Arteries: Design and Rationale of the DISCOVER INOCA Prospective, Multicenter Registry. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102046. PMID: 39132594, PMCID: PMC11308755, DOI: 10.1016/j.jscai.2024.102046.Peer-Reviewed Original ResearchCoronary function testingObstructive coronary artery diseaseCoronary artery diseaseNonobstructive coronary arteriesLong-term outcomesFollow-upVasomotor disordersEnd pointsComposite of cardiovascular deathCoronary arteryLong-term follow-upCoronary microvascular dysfunctionDiagnostic coronary angiographyCardiovascular adverse eventsAdverse cardiovascular eventsCoronary vasomotor disordersOptical coherence tomographySymptomatic myocardial bridgingShort-term end pointsAtherosclerotic plaque burdenIschemic heart diseaseLong-term end pointsINOCA patientsAcetylcholine provocationPatient-reported outcome measuresEvaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA)
Maayah M, Latif N, Vijay A, Gallegos C, Cigarroa N, Martinez E, Mazure C, Miller E, Spatz E, Shah S. Evaluating Ischemic Heart Disease in Women: Focus on Angina With Nonobstructive Coronary Arteries (ANOCA). Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 102195. PMID: 39166160, PMCID: PMC11330936, DOI: 10.1016/j.jscai.2024.102195.Peer-Reviewed Original ResearchIschemic heart diseaseNonobstructive coronary arteriesCoronary artery diseaseArtery diseaseObstructive coronary artery diseaseCoronary arteryLong-term cardiovascular prognosisHeart diseaseSuspected ischemic heart diseaseAtherosclerotic coronary artery diseaseCoronary vasomotor disordersPretest probability of diseasePragmatic diagnostic algorithmExpert consensus documentEvaluating ischemic heart diseaseImpact quality of lifeQuality of lifeSymptomatic patientsPretest probabilityANOCACardiovascular prognosisVasomotor disordersDiagnostic evaluationPersistent symptomsDiagnostic strategies
2024
Symptom assessment and angina classification of patients with ischemia and nonobstructive coronary arteries undergoing invasive coronary function testing: from the DISCOVER INOCA multicenter registry
Shah S, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Samuels B, Lerman A, Moses J, Zhang Z, Tirziu D, Chamie D, Lansky A. Symptom assessment and angina classification of patients with ischemia and nonobstructive coronary arteries undergoing invasive coronary function testing: from the DISCOVER INOCA multicenter registry. European Heart Journal 2024, 45: ehae666.1617. DOI: 10.1093/eurheartj/ehae666.1617.Peer-Reviewed Original ResearchCoronary function testingCoronary microvascular dysfunctionInvasive coronary function testingNonobstructive coronary arteriesCanadian Cardiovascular SocietyVasospastic anginaAngina classificationCoronary flow reserveMulticenter registryClassification of patientsChest painCoronary angiographyFemale patientsCMD groupFunction testsAverage coronary flow reserveCoronary arteryPost-procedure diagnosesVasospastic angina groupPatients 4%Coronary vasomotor disordersSymptomatic myocardial bridgingRest symptomsShortness of breathDiagnostic phenotypesTCT-677 Evaluating Ischemia With Nonobstructive Coronary Arteries Using Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry
Shah S, Tremmel J, Smilowitz N, Prasad M, Kobayashi Y, Henry T, Henry G, Samady H, Samuels B, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamie D, Henrici K, Latif N, Cigarroa N, Lansky A. TCT-677 Evaluating Ischemia With Nonobstructive Coronary Arteries Using Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b260. DOI: 10.1016/j.jacc.2024.09.802.Peer-Reviewed Original ResearchTCT-352 How Accurately Intravascular Imaging Metrics Predict Coronary Physiology? A Lesion-Level Meta-analysis
Chamie D, Bahl R, Bandeira D, Johnson T, Maehara A, Shah S, Ali Z, Cervone A, Escaned J, Al-Lamee R, Pfau S, Nijjer S, Stone G, Lansky A, Mintz G, Petraco R. TCT-352 How Accurately Intravascular Imaging Metrics Predict Coronary Physiology? A Lesion-Level Meta-analysis. Journal Of The American College Of Cardiology 2024, 84: b91-b92. DOI: 10.1016/j.jacc.2024.09.406.Peer-Reviewed Original ResearchTCT-674 Diagnosis of Coronary Microvascular Dysfunction With Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry
Shah S, Samuels B, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Cristea E, Chamie D, Henrici K, Latif N, Cigarroa N, Lansky A. TCT-674 Diagnosis of Coronary Microvascular Dysfunction With Invasive Coronary Function Testing: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b258-b259. DOI: 10.1016/j.jacc.2024.09.799.Peer-Reviewed Original ResearchTCT-671 Evaluation of Coronary Tortuosity in Patients With Ischemia and No Coronary Artery Disease: Insights From the DISCOVER INOCA Multicenter Registry
Sohal S, Cristea E, Higney J, Williams O, Ohadi L, Samuels B, Tremmel J, Henry T, Smilowitz N, Prasad M, Kobayashi Y, Henry G, Samady H, Lerman A, Moses J, Pietras C, Zhang Z, Tirziu D, Parise H, Chamie D, Henrici K, Latif N, Lansky A, Shah S. TCT-671 Evaluation of Coronary Tortuosity in Patients With Ischemia and No Coronary Artery Disease: Insights From the DISCOVER INOCA Multicenter Registry. Journal Of The American College Of Cardiology 2024, 84: b258. DOI: 10.1016/j.jacc.2024.09.796.Peer-Reviewed Original ResearchLong-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis
Odanović N, Schwann A, Zhang Z, Kapadia S, Kunnirickal S, Parise H, Tirziu D, Ilic I, Lansky A, Pietras C, Shah S. Long-term outcomes of ischaemia with no obstructive coronary artery disease (INOCA): a systematic review and meta-analysis. Open Heart 2024, 11: e002852. PMID: 39353703, PMCID: PMC11448144, DOI: 10.1136/openhrt-2024-002852.Peer-Reviewed Original ResearchConceptsCoronary Vasomotor Disorders International Study GroupRate of MACEReduced coronary flow reserveCoronary flow reservePrognosis of patientsVasospastic anginaPatient yearsMyocardial infarctionPrimary outcomeIncidence of primary outcomeLong-term prognosis of patientsSystematic reviewMeta-analysisLong-term prognosisInternational Study GroupAdverse cardiovascular eventsLong-term outcomesImaging stress testsMeta-analysis of studiesRandom-effects modelWeb of ScienceINOCACardiovascular eventsFollow-upVasomotor disordersAssociation between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain
Gallegos C, Paredes C, Hu J, Posada E, Saito Y, Lansky A, Shah S, Liu Y, Smolderen K, Mena-Hurtado C, Sinusas A, Miller E. Association between 82Rb positron emission tomography-derived regional myocardial blood flow, severity of angiographic coronary artery stenosis, and mortality in patients with chest pain. Advances In Radiotherapy & Nuclear Medicine 2024, 2: 3786. DOI: 10.36922/arnm.3786.Peer-Reviewed Original ResearchMyocardial flow reserveGlobal myocardial flow reserveQuantitative coronary angiographyAssociated with increased all-cause mortalityPositron emission tomographyCoronary artery stenosis severityMyocardial blood flowAll-cause mortalityCoronary angiographyChest painStenosis severityAngiographic coronary artery stenosisResting myocardial blood flowAcute chest painBlood flowInvasive coronary angiographyLeft circumflex arteryLeft descending arteryRight coronary arteryCoronary artery stenosisStress testCoronary stenosis severityCardiovascular eventsDescending arteryWeak correlationDiagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries.
Cigarroa N, Latif N, Maayah M, Khokhar A, Kunnirickal S, Schwann A, Maciejewski K, Odanovic N, Mazure C, Spatz E, Pfau S, Lansky A, Shah S. Diagnostic Yield and Clinical Utility of Coronary Angiography Versus Coronary Function Testing in Women With Angina and Nonobstructive Coronary Arteries. Journal Of The American Heart Association 2024, 13: e035852. PMID: 39291500, DOI: 10.1161/jaha.124.035852.Peer-Reviewed Original ResearchCoronary function testingNonobstructive coronary arteriesInvasive coronary angiographyCoronary microvascular dysfunctionCoronary angiographyVasomotor disordersFunction testsCoronary arteryAntianginal therapyDiagnostic yieldVasospastic anginaMicrovascular dysfunctionDiagnostic yield of invasive coronary angiographyNonobstructive coronary artery diseaseSuspected ischemic heart diseaseCalcium channel blockersCoronary vasomotor disordersSymptomatic myocardial bridgingCoronary artery diseaseIschemic heart diseaseChannel blockersAnatomic diagnosisEndothelial dysfunctionArtery diseaseMyocardial bridgingThe Path to a Match for Interventional Cardiology Fellowship: A Major SCAI Initiative
Douglas E. Drachman, Tayo Addo, Robert J. Applegate, Robert C. Bartel, Anna E. Bortnick, Francesca M. Dea, Tarek Helmy, Timothy D. Henry, Adnan Khalif, Ajay J. Kirtane, Michael Levy, Michael J. Lim, Ehtisham Mahmud, Nino Mihatov, Sahil A. Parikh, Laura Porter, Abhiram Prasad, Sunil V. Rao, Louai Razzouk, Samit Shah, Adhir Shroff, Jacqueline E. Tamis-Holland, Poonam Velagapudi, Fredrick G. Welt, J. Dawn Abbott, The Path to a Match for Interventional Cardiology Fellowship: A Major SCAI Initiative, Journal of the Society for Cardiovascular Angiography & Interventions, Volume 3, Issue 7, 2024, 101980, ISSN 2772-9303Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsFinding the Optimal Strategy for Nonculprit Revascularization in Acute Myocardial Infarction: The Role of Angiography-Derived Physiology
Odanovic N, Parikh R, Shah S. Finding the Optimal Strategy for Nonculprit Revascularization in Acute Myocardial Infarction: The Role of Angiography-Derived Physiology. Circulation Cardiovascular Interventions 2024, 17: e014129. PMID: 38771908, DOI: 10.1161/circinterventions.124.014129.Commentaries, Editorials and LettersClinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach.
Regan C, Scierka L, Dardik A, Tonnessen B, Iyad Ochoa Chaar C, Ionescu C, Aboian E, Cardella J, Nassiri N, Guzman R, Attaran R, Nagpal S, Shah S, Smolderen K, Mena-Hurtado C. Clinician perspectives regarding CYP2C19 genotype testing in patients with critical limb ischemia: A Delphi approach. Vascular 2024, 17085381241246318. PMID: 38669051, DOI: 10.1177/17085381241246318.Peer-Reviewed Original ResearchDual antiplatelet therapyPeripheral arterial diseaseCYP2C19 testingCYP2C19 mutationsHeterogeneity of treatment effectsPeripheral vascular interventionsConsensus statementKnowledge questionsAntiplatelet therapyGenetic testingVascular surgeryAcademic health systemBarriers to implementationInterquartile rangeCYP2C19 genotype testingVascular diseaseInterventional cardiologyModified Delphi methodPatient's metabolic statusManagement of patientsCritical limb ischemiaPerceived barriersPeripheral vascular diseaseArterial vascular diseaseClinician perspectivesReal-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program
Gonzalez P, Hebbe A, Hussain Y, Khera R, Banerjee S, Plomondon M, Waldo S, Pfau S, Curtis J, Shah S. Real-World Experience and Outcomes With Percutaneous Coronary Intervention for Protected Versus Unprotected Left Main Coronary Artery Disease: Insights from the Veteran Affairs Clinical Assessment Reporting and Tracking Program. The American Journal Of Cardiology 2024, 222: 39-50. PMID: 38677666, DOI: 10.1016/j.amjcard.2024.04.039.Peer-Reviewed Original ResearchULM percutaneous coronary interventionPercutaneous coronary interventionPropensity-matched cohortMyocardial infarctionCoronary interventionAll-cause mortalityTracking programUS clinical practiceOne-year MACEOne-year outcomesIncidence of rehospitalizationAdverse cardiovascular eventsUnprotected left main coronary artery diseaseAcute coronary syndromeCoronary artery diseaseRates of MIMechanical circulatory supportLeft main percutaneous coronary interventionPCI patientsUrgent revascularizationPractice patternsCart programLeft main bifurcationPrimary outcomeMatched cohort