2006
Nitric oxide modulates glutathione synthesis during endotoxemia
Payabvash S, Ghahremani MH, Goliaei A, Mandegary A, Shafaroodi H, Amanlou M, Dehpour AR. Nitric oxide modulates glutathione synthesis during endotoxemia. Free Radical Biology And Medicine 2006, 41: 1817-1828. PMID: 17157184, DOI: 10.1016/j.freeradbiomed.2006.09.010.Peer-Reviewed Original ResearchConceptsNitric oxide synthesisOxide synthesisHepatic glutathione synthesisGlutathione levelsGlutathione synthesisInjection of lipopolysaccharideHepatic glutathione concentrationHepatic glutathione levelsEndotoxin-induced changesNitric oxide formationIntracellular glutathione levelsEndotoxemic miceLiver glutathioneEndotoxemiaNitric oxideGlutathione peroxidaseGlutathione fluxOxidative stressGlutathione concentrationGlutathione statusAntioxidant defenseGlutathione S-transferaseCysteine precursorLipopolysaccharideGlutathione metabolismNaltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats
Ebrahimkhani MR, Kiani S, Oakley F, Kendall T, Shariftabrizi A, Tavangar SM, Moezi L, Payabvash S, Karoon A, Hoseininik H, Mann DA, Moore KP, Mani AR, Dehpour AR. Naltrexone, an opioid receptor antagonist, attenuates liver fibrosis in bile duct ligated rats. Gut 2006, 55: 1606. PMID: 16543289, PMCID: PMC1860108, DOI: 10.1136/gut.2005.076778.Peer-Reviewed Original ResearchConceptsHepatic stellate cellsProcollagen I expressionHepatic fibrosisBile ductSelective delta-opioid receptor agonistI expressionDelta-opioid receptor agonistAlpha-smooth muscle actinCultured hepatic stellate cellsOpioid receptor antagonistHepatic hydroxyproline levelsEffects of naltrexoneOpioid receptor agonistsHepatic GSH/GSSG ratioReverse transcriptase-polymerase chain reactionTIMP-1 expressionRat hepatic stellate cellsMMP-2 activityTranscriptase-polymerase chain reactionSmooth muscle actinMatrix metalloproteinase-2GSH/GSSG ratioDelta1 receptorsActivated Rat Hepatic Stellate CellsBiliary cirrhosis
2005
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sciences 2005, 76: 2497-2512. PMID: 15763080, DOI: 10.1016/j.lfs.2004.12.009.Peer-Reviewed Original ResearchConceptsBile duct ligationChronic L-NAME treatmentL-NAME treatmentPlasma Hcy concentrationPlasma HcyDuct ligationBiliary cirrhosisBDL ratsHcy concentrationsSAH ratioNitric oxideSecondary biliary cirrhosisWeeks of cholestasisImpaired liver functionModel of cirrhosisHcy elevationMethionine overloadPrecirrhotic stageSubsequent cirrhosisLiver functionObstructive cholestasisHepatic fibrogenesisHcy metabolismUnoperated ratsCholestasis