Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sciences 2005, 76: 2497-2512. PMID: 15763080, DOI: 10.1016/j.lfs.2004.12.009.Peer-Reviewed Original ResearchConceptsBile duct ligationChronic L-NAME treatmentL-NAME treatmentPlasma Hcy concentrationPlasma HcyDuct ligationBiliary cirrhosisBDL ratsHcy concentrationsSAH ratioNitric oxideSecondary biliary cirrhosisWeeks of cholestasisImpaired liver functionModel of cirrhosisHcy elevationMethionine overloadPrecirrhotic stageSubsequent cirrhosisLiver functionObstructive cholestasisHepatic fibrogenesisHcy metabolismUnoperated ratsCholestasis