Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat
Golestani A, Rastegar R, Shariftabrizi A, Khaghani S, Payabvash SM, Salmasi AH, Dehpour AR, Pasalar P. Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat. Clinica Chimica Acta 2005, 365: 153-159. PMID: 16183047, DOI: 10.1016/j.cca.2005.08.008.Peer-Reviewed Original ResearchConceptsDosing groupVitamin ESOD activityAntioxidant capacitySignificant decreaseErythrocyte SOD activityPlasma antioxidant capacityVitamin E/Significant increaseEndogenous antioxidant systemNon-toxic dosesDose-dependent mannerTotal antioxidant capacitySerum levelsSame dosesBody weightNontoxic dosesWeeksControl levelsTime-dependent regulationAntioxidant defenseDosesSuperoxide dismutaseRatsAntioxidant system