2006
Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver
Payabvash S, Beheshtian A, Salmasi AH, Kiumehr S, Ghahremani MH, Tavangar SM, Sabzevari O, Dehpour AR. Chronic morphine treatment induces oxidant and apoptotic damage in the mice liver. Life Sciences 2006, 79: 972-980. PMID: 16750225, DOI: 10.1016/j.lfs.2006.05.008.Peer-Reviewed Original ResearchConceptsChronic morphine treatmentMorphine treatmentMorphine administrationHigh dosesInduction of apoptosisInduction of liverHepatic glutathione concentrationAntioxidant defenseLiver antioxidant defensesObserved adverse effectsPro-oxidant effectsCancer painEnzymatic antioxidant defensesOpioid analgesicsChronic painOpioid drugsTumor spreadOpioid receptorsSame dosesHepatotoxic effectsProtective roleTumor growthLow dosesMorphineHepatocyte apoptosis
2005
Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat
Golestani A, Rastegar R, Shariftabrizi A, Khaghani S, Payabvash SM, Salmasi AH, Dehpour AR, Pasalar P. Paradoxical dose- and time-dependent regulation of superoxide dismutase and antioxidant capacity by vitamin E in rat. Clinica Chimica Acta 2005, 365: 153-159. PMID: 16183047, DOI: 10.1016/j.cca.2005.08.008.Peer-Reviewed Original ResearchConceptsDosing groupVitamin ESOD activityAntioxidant capacitySignificant decreaseErythrocyte SOD activityPlasma antioxidant capacityVitamin E/Significant increaseEndogenous antioxidant systemNon-toxic dosesDose-dependent mannerTotal antioxidant capacitySerum levelsSame dosesBody weightNontoxic dosesWeeksControl levelsTime-dependent regulationAntioxidant defenseDosesSuperoxide dismutaseRatsAntioxidant system