2006
Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis
Kiani S, Ebrahimkhani MR, Shariftabrizi A, Doratotaj B, Payabvash S, Riazi K, Dehghani M, Honar H, Karoon A, Amanlou M, Tavangar SM, Dehpour AR. Opioid system blockade decreases collagenase activity and improves liver injury in a rat model of cholestasis. Journal Of Gastroenterology And Hepatology 2006, 22: 406-413. PMID: 17295775, DOI: 10.1111/j.1440-1746.2006.04260.x.Peer-Reviewed Original ResearchConceptsOpioid receptor blockadeLiver injuryMMP-2 activityNaltrexone treatmentReceptor blockadeCholestasis-induced liver injuryPlasma nitrite/nitrateNitrite/nitrate levelsMatrix metalloproteinase-2 activitySAH ratioManifestation of cholestasisOpioid agonist administrationSham-operated ratsMetalloproteinase-2 activityLiver enzyme activitiesNitrite/nitrateLiver SAM levelsPlasma enzyme activitiesSAM levelsAgonist administrationBDL animalsCholestatic animalsEndogenous opioidsBDL ratsS-adenosylhomocysteine content
2005
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sciences 2005, 76: 2497-2512. PMID: 15763080, DOI: 10.1016/j.lfs.2004.12.009.Peer-Reviewed Original ResearchConceptsBile duct ligationChronic L-NAME treatmentL-NAME treatmentPlasma Hcy concentrationPlasma HcyDuct ligationBiliary cirrhosisBDL ratsHcy concentrationsSAH ratioNitric oxideSecondary biliary cirrhosisWeeks of cholestasisImpaired liver functionModel of cirrhosisHcy elevationMethionine overloadPrecirrhotic stageSubsequent cirrhosisLiver functionObstructive cholestasisHepatic fibrogenesisHcy metabolismUnoperated ratsCholestasis