2007
Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress
Payabvash S, Kiumehr S, Nezami BG, Zandieh A, Anvari P, Tavangar SM, Dehpour AR. Endogenous opioids modulate hepatocyte apoptosis in a rat model of chronic cholestasis: the role of oxidative stress. Liver International 2007, 27: 538-547. PMID: 17403194, DOI: 10.1111/j.1478-3231.2007.01457.x.Peer-Reviewed Original ResearchConceptsAnti-oxidant balanceBile duct ligationChronic cholestasisEndogenous opioidsCholestatic ratsHepatocyte apoptosisOpioid antagonistRat modelHepatic lipid peroxidation levelsSerum liver enzymesCholestatic liver diseaseEndogenous opioid systemHepatic glutathione levelsAnti-oxidant defensesLipid peroxidation levelsAnti-oxidant enzyme activitiesChronic treatmentNaltrexone treatmentCholestatic animalsLiver diseaseBDL ratsHepatic damageDuct ligationLiver enzymesCholestasis
2005
Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis
Ebrahimkhani MR, Sadeghipour H, Dehghani M, Kiani S, Payabvash S, Riazi K, Honar H, Pasalar P, Mirazi N, Amanlou M, Farsam H, Dehpour AR. Homocysteine alterations in experimental cholestasis and its subsequent cirrhosis. Life Sciences 2005, 76: 2497-2512. PMID: 15763080, DOI: 10.1016/j.lfs.2004.12.009.Peer-Reviewed Original ResearchConceptsBile duct ligationChronic L-NAME treatmentL-NAME treatmentPlasma Hcy concentrationPlasma HcyDuct ligationBiliary cirrhosisBDL ratsHcy concentrationsSAH ratioNitric oxideSecondary biliary cirrhosisWeeks of cholestasisImpaired liver functionModel of cirrhosisHcy elevationMethionine overloadPrecirrhotic stageSubsequent cirrhosisLiver functionObstructive cholestasisHepatic fibrogenesisHcy metabolismUnoperated ratsCholestasis