Featured Publications
Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR
Lang SM, Bynoe MO, Karki R, Tartell MA, Means RE. Kaposi’s Sarcoma-Associated Herpesvirus K3 and K5 Proteins Down Regulate Both DC-SIGN and DC-SIGNR. PLOS ONE 2013, 8: e58056. PMID: 23460925, PMCID: PMC3584050, DOI: 10.1371/journal.pone.0058056.Peer-Reviewed Original ResearchAmino Acid MotifsCell Adhesion MoleculesCell MembraneDown-RegulationEndocytosisHEK293 CellsHerpesvirus 8, HumanHumansImmunoprecipitationLectins, C-TypeLysosomesProteasome Endopeptidase ComplexProtein StabilityProtein Structure, TertiaryProteolysisReceptors, Cell SurfaceStructure-Activity RelationshipTyrosineUbiquitinationViral Proteins
2002
The First HxRxG Motif in Simian Immunodeficiency Virus mac239 Vpr Is Crucial for G2/M Cell Cycle Arrest
Mueller S, Lang S. The First HxRxG Motif in Simian Immunodeficiency Virus mac239 Vpr Is Crucial for G2/M Cell Cycle Arrest. Journal Of Virology 2002, 76: 11704-11709. PMID: 12388729, PMCID: PMC136740, DOI: 10.1128/jvi.76.22.11704-11709.2002.Peer-Reviewed Original ResearchConceptsCell cycle arrestCell cycle arrest functionCycle arrestArrest functionVpr mutantsAlpha-helical domainAlpha-helical regionG2/M cell cycle arrestLong terminal repeatM cell cycle arrestNuclear importArrest of cellsSIV long terminal repeatTranscriptional transactivationPreintegration complexSecond motifFunctional domainsReduced transactivationVpr proteinTerminal repeatAmino acidsTransactivationSingle substitutionMotifMutants