Featured Publications
KDM5 histone demethylases repress immune response via suppression of STING
Wu L, Cao J, Cai WL, Lang SM, Horton JR, Jansen DJ, Liu ZZ, Chen JF, Zhang M, Mott BT, Pohida K, Rai G, Kales SC, Henderson MJ, Hu X, Jadhav A, Maloney DJ, Simeonov A, Zhu S, Iwasaki A, Hall MD, Cheng X, Shadel GS, Yan Q. KDM5 histone demethylases repress immune response via suppression of STING. PLOS Biology 2018, 16: e2006134. PMID: 30080846, PMCID: PMC6095604, DOI: 10.1371/journal.pbio.2006134.Peer-Reviewed Original ResearchConceptsImmune responseSTING expressionCyclic GMP-AMP synthase stimulatorSuppression of STINGCancer cellsCancer immunotherapy agentsHuman papilloma virusAdaptive immune responsesMultiple clinical trialsExpression of STINGBreast cancer cellsInnate immune defenseRobust interferon responseMultiple cancer typesIntratumoral CD8Immunotherapy agentsAnticancer immunotherapyPatient survivalNeck cancerPapilloma virusClinical trialsT cellsSTING agonistsKDM5 histonePositive head
2002
Korrelation von FDG-PET und MRT/CT mit der Histopathologie in Primärdiagnostik, Lymphknotenstaging und Rezidivdiagnostik von Kopf-Hals-Tumoren
Pöpperl G, Lang S, Dagdelen O, Jäger L, Tiling R, Hahn K, Tatsch K. Korrelation von FDG-PET und MRT/CT mit der Histopathologie in Primärdiagnostik, Lymphknotenstaging und Rezidivdiagnostik von Kopf-Hals-Tumoren. RöFo 2002, 174: 714-720. PMID: 12063600, DOI: 10.1055/s-2002-32215.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedDiagnosis, DifferentialFemaleFluorodeoxyglucose F18HumansLymph NodesLymphatic MetastasisMagnetic Resonance ImagingMaleMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingNeoplasms, Unknown PrimaryOtorhinolaryngologic NeoplasmsPrognosisRetrospective StudiesSensitivity and SpecificityTomography, Emission-ComputedTomography, X-Ray ComputedConceptsLymph node metastasisCervical lymph node metastasisDiagnosis of primary tumorLymph node involvementPrimary tumorPre-surgical diagnosisTumor recurrenceNode metastasisFDG-PETNode involvementPrimary lesionHistopathological findingsDiagnostic value of FDG-PETStaging of head and neck cancerPrimary lymph node involvementDiagnosis of tumor recurrenceHead and neck cancerTumor diameter <Occult primary tumorDetect tumor recurrenceMorphological imaging modalitiesRecurrent tumorsPT1 stageNeck cancerPatient prognosis