2011
Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization
Xue Y, Lee S, Ha Y. Crystal structure of amyloid precursor-like protein 1 and heparin complex suggests a dual role of heparin in E2 dimerization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2011, 108: 16229-16234. PMID: 21930949, PMCID: PMC3182750, DOI: 10.1073/pnas.1103407108.Peer-Reviewed Original Research
2000
Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity
Kim H, Park C, Ho S, Lee J, Lee S, Kim Y, Rah J, Jeong S, Suh Y. Carboxyl‐terminal fragment of Alzheimer's APP destabilizes calcium homeostasis and renders neuronal cells vulnerable to excitotoxicity. The FASEB Journal 2000, 14: 1508-1517. DOI: 10.1096/fj.99-0809com.Peer-Reviewed Original ResearchAmyloid precursor proteinGlutamate-induced excitotoxicityAlzheimer amyloid precursor proteinPrimary cortical neuronsSK-N-SHCalcium homeostasisAlzheimer's diseaseNeuronal cellsCortical neuronsRecombinant carboxy-terminal 105 amino acid fragmentPC-12 cellsCarboxyl-terminal fragmentRat primary cortical neuronsSK-N-SH cellsIntracellular calcium concentrationLong-term potentiationNeurotoxicity characteristicNeuropathological changesMK-801Rat hippocampusAmyloid β-peptideAβ1-42ExcitotoxicityCalcium increaseInward currents