2000
Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
Artandi S, Chang S, Lee S, Alson S, Gottlieb G, Chin L, DePinho R. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 2000, 406: 641-645. PMID: 10949306, DOI: 10.1038/35020592.Peer-Reviewed Original ResearchConceptsEpithelial cancersSoft tissue sarcomasTelomere lengthP53 mutant miceTumor suppressor gene mutationsSuppressor gene mutationsNon-reciprocal translocationsTissue sarcomasTelomere dysfunctionAged humansMutant miceCytogenetic featuresCancerMiceHuman carcinomasGene mutationsEpithelial renewalTelomerase expressionCritical reductionCarcinomaDysfunctionHigh rateReverse transcriptaseEukaryotic chromosomesNucleoprotein complexes
1999
Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice
Rudolph K, Chang S, Lee H, Blasco M, Gottlieb G, Greider C, DePinho R. Longevity, Stress Response, and Cancer in Aging Telomerase-Deficient Mice. Cell 1999, 96: 701-712. PMID: 10089885, DOI: 10.1016/s0092-8674(00)80580-2.Peer-Reviewed Original ResearchConceptsOrganismal aging processTelomerase-null miceTelomerase-deficient miceTelomere functionOrganismal levelTelomere maintenanceCellular senescenceOverall fitnessPhysiological processesStress responseHematopoietic ablationGenetic instabilityTelomere lengthNull miceCritical roleLife spanWound healingAging processSpontaneous malignanciesSenescenceOrganismsFitnessPathophysiological symptomsRoleMice