2016
TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions
Rai R, Chen Y, Lei M, Chang S. TRF2-RAP1 is required to protect telomeres from engaging in homologous recombination-mediated deletions and fusions. Nature Communications 2016, 7: 10881. PMID: 26941064, PMCID: PMC4785230, DOI: 10.1038/ncomms10881.Peer-Reviewed Original ResearchConceptsRepressor/activator protein 1Telomere length controlTranscriptional gene regulationRepair of telomeresTelomere end protectionNon-homologous endActivator protein-1Myb domainChromosome fusionsYeast Rap1Gene regulationHDR pathwayEnd protectionBasic domainTelomere lossTelomeresHuman cellsHR factorsProtein 1Length controlPARP1Free fusionInappropriate processingTRF2Important role
2009
Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance
Atanassov BS, Evrard YA, Multani AS, Zhang Z, Tora L, Devys D, Chang S, Dent SY. Gcn5 and SAGA Regulate Shelterin Protein Turnover and Telomere Maintenance. Molecular Cell 2009, 35: 352-364. PMID: 19683498, PMCID: PMC2749492, DOI: 10.1016/j.molcel.2009.06.015.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedChromosome AberrationsDNA Breaks, Double-StrandedDNA RepairGene DeletionHumansMiceModels, BiologicalP300-CBP Transcription FactorsProteasome InhibitorsProtein StabilityShelterin ComplexTelomereTelomere-Binding ProteinsTelomeric Repeat Binding Protein 1Thiolester HydrolasesUbiquitin ThiolesteraseConceptsSAGA complexTelomeric shelterin complexDeletion of GCN5Accessibility of chromatinBona fide componentTRF1 levelsGene regulationShelterin complexTelomere maintenanceMammalian cellsTranscription factorsGCN5DNA repairFide componentRepair proteinsTelomere dysfunctionProtein turnoverHuman cellsUbiquitin-specific protease 22Biochemical studiesOverexpression of USP22USP22ComplexesTurnoverChromatin