2014
Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A
Gupta R, Dong Y, Solomon PD, Wettersten HI, Cheng CJ, Min JN, Henson J, Dogra SK, Hwang SH, Hammock BD, Zhu LJ, Reddel RR, Saltzman WM, Weiss RH, Chang S, Green MR, Wajapeyee N. Synergistic tumor suppression by combined inhibition of telomerase and CDKN1A. Proceedings Of The National Academy Of Sciences Of The United States Of America 2014, 111: e3062-e3071. PMID: 25024194, PMCID: PMC4121806, DOI: 10.1073/pnas.1411370111.Peer-Reviewed Original ResearchConceptsP53-mediated transcriptional activationCyclin-dependent kinase inhibitor 1AMutant p53Telomerase inhibitionTumor suppressor p53Transcriptional activationSynergistic tumor suppressionTelomere dysfunctionCheckpoint proteinsP53 upregulated modulatorTumor suppressionCDK inhibitorsSuppressor p53Inhibitor 1AP53 activityTelomeraseHuman cancersCancer cell linesApoptosis inductionPharmacological inhibitionApoptosisCell linesPharmacological restorationP21Growth inhibition
2004
UV-Induced B-Cell Lymphomas in p53 Heterozygous Mice.
Miyahara Y, Kazimi N, Multani A, Pathak S, Chang S, Angkasekwinai Y, Qin X, Ullrich S. UV-Induced B-Cell Lymphomas in p53 Heterozygous Mice. Blood 2004, 104: 1370. DOI: 10.1182/blood.v104.11.1370.1370.Peer-Reviewed Original ResearchB-cell lymphomaP53 heterozygous miceHeterozygous miceLymph nodesTumor cellsBone marrowUV-induced skin cancerUV-irradiated miceNon-skin cancerB-cell originWild-type miceUseful animal modelCell linesSkin cancer inductionSystemic immunosuppressionIL-10Mature B cellsFS40 sunlampsAggressive tumorsLymphoid organsSubcutaneous injectionB7-1B7-2Spleen cellsLymphoid malignancies
1996
Establishment of an in vitro cell model system to study human prostate carcinogenesis.
Ozen M, Multani A, Chang S, Voneschenbach A, Chung L, Pathak S. Establishment of an in vitro cell model system to study human prostate carcinogenesis. International Journal Of Oncology 1996, 8: 883-8. PMID: 21544441, DOI: 10.3892/ijo.8.5.883.Peer-Reviewed Original ResearchChromosome 5Tumor suppressorPassage cellsMolecular cytogenetic methodsHuman prostate carcinogenesisCell strainsLate passagesCell linesCell model systemNear-diploid cellsLate passage cellsSame chromosomeProstate carcinogenesisCertain genesEarly passage cellsHigh passage cellsQ armProstate cancer cell linesMetastatic phenotypeChromosome constitutionNormal copyCancer cell linesCytogenetic methodsLong armGenetic alterations