2019
Age-Related Changes in Immune Regulation by Noncoding RNAs
Wang W, Qian F, Montgomery R. Age-Related Changes in Immune Regulation by Noncoding RNAs. 2019, 1241-1258. DOI: 10.1007/978-3-319-99375-1_109.Peer-Reviewed Original ResearchCellular stress responseNumerous biological processesUnderstanding of immunosenescenceCellular proteinsNoncoding RNAsGenomic instabilityReactive oxygen speciesCellular agingBiological processesStress responseAging pathwaysImportant regulatorDNA damageMitochondrial dysfunctionCellular mechanismsInefficient autophagyOxidative damageOxygen speciesRNAFundamental roleRecent studiesMechanisms of immunosenescenceImmune regulationNcRNAsAccumulation
2017
Age-Related Changes in Immune Regulation by Noncoding RNAs
Wang W, Qian F, Montgomery R. Age-Related Changes in Immune Regulation by Noncoding RNAs. 2017, 1-18. DOI: 10.1007/978-3-319-64597-1_109-1.Peer-Reviewed Original ResearchCellular stress responseNumerous biological processesUnderstanding of immunosenescenceCellular proteinsNoncoding RNAsGenomic instabilityReactive oxygen speciesCellular agingBiological processesStress responseAging pathwaysImportant regulatorDNA damageMitochondrial dysfunctionCellular mechanismsInefficient autophagyOxidative damageOxygen speciesRNAFundamental roleRecent studiesMechanisms of immunosenescenceImmune regulationNcRNAsAccumulation
2014
Effect of aging on microRNAs and regulation of pathogen recognition receptors
Olivieri F, Procopio AD, Montgomery RR. Effect of aging on microRNAs and regulation of pathogen recognition receptors. Current Opinion In Immunology 2014, 29: 29-37. PMID: 24769423, PMCID: PMC4119513, DOI: 10.1016/j.coi.2014.03.006.Peer-Reviewed Original ResearchConceptsInnate immune recognitionImmune innate responseResolution of inflammationPathogen recognition receptorsTLR signalsUnderstanding of immunosenescenceProinflammatory responseImmune responseNF-κBInnate responseImmune recognitionRecognition receptorsActive investigationImmunosenescenceDownstream effectorsRecent studiesNegative regulatorSimilar regulatory activitiesResponseMiRNAsInflammationMicroRNAsAging-associated miRNAsVaccine
2012
Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood.
Qian F, Montgomery RR. Quantitative imaging of lineage-specific Toll-like receptor-mediated signaling in monocytes and dendritic cells from small samples of human blood. Journal Of Visualized Experiments 2012 PMID: 22525943, PMCID: PMC3466655, DOI: 10.3791/3741.Peer-Reviewed Original ResearchConceptsToll-like receptorsDendritic cellsImmune responseToll-like receptor-mediated signalingCell-mediated immune responsesCertain Toll-like receptorsAntigen-presenting cellsPeripheral blood monocytesHealthy human donorsNF-κB pathwayInnate immune systemReceptor-mediated signalingQuantitative flow cytometryTLR levelsWest Nile virusPatient susceptibilityUnderstanding of immunosenescenceImmune responsivenessElderly donorsLarge cohortOlder donorsAdaptive immunityBlood monocytesNF-κBTherapeutic interventions