2023
Platelet response to influenza vaccination reflects effects of aging
Konstorum A, Mohanty S, Zhao Y, Melillo A, Vander Wyk B, Nelson A, Tsang S, Blevins T, Belshe R, Chawla D, Rondina M, Gill T, Montgomery R, Allore H, Kleinstein S, Shaw A. Platelet response to influenza vaccination reflects effects of aging. Aging Cell 2023, 22: e13749. PMID: 36656789, PMCID: PMC9924941, DOI: 10.1111/acel.13749.Peer-Reviewed Original ResearchConceptsCommunity-dwelling older adultsPlatelet activationOlder adultsInfluenza vaccinationAge-associated chronic inflammationInfluence platelet functionRNA expressionPro-inflammatory diseasesAge-associated increasePlatelet activation pathwaysAge-associated differencesActivation pathwayPlatelet transcriptomeGeriatric conditionsChronic inflammationImmune responsePlatelet functionPlatelet responseSNF residentsVaccinationActivation responseYoung individualsProtein levelsAdultsYounger participants
2016
Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny
Malawista A, Wang X, Trentalange M, Allore HG, Montgomery RR. Coordinated expression of tyro3, axl, and mer receptors in macrophage ontogeny. Macrophage 2016, 3: e1261. PMID: 27695708, PMCID: PMC5040214, DOI: 10.14800/macrophage.1261.Peer-Reviewed Original ResearchTAM receptorsTherapeutic interventionsTAM receptor expressionPro-inflammatory cytokinesToll-like receptorsPotential therapeutic interventionsSignificant differencesMacrophage ontogenyUpregulation of expressionTriple-mutant miceLymphoproliferative disordersHomologous receptor tyrosine kinasesTAM expressionReceptor expressionM receptorMutant miceHuman macrophagesMonocytesReceptor tyrosine kinasesMacrophagesAxlProtein levelsReceptorsTyro3Human subjects