2003
Calprotectin, an Abundant Cytosolic Protein from Human Polymorphonuclear Leukocytes, Inhibits the Growth of Borrelia burgdorferi
Lusitani D, Malawista SE, Montgomery RR. Calprotectin, an Abundant Cytosolic Protein from Human Polymorphonuclear Leukocytes, Inhibits the Growth of Borrelia burgdorferi. Infection And Immunity 2003, 71: 4711-4716. PMID: 12874352, PMCID: PMC166021, DOI: 10.1128/iai.71.8.4711-4716.2003.Peer-Reviewed Original ResearchConceptsPolymorphonuclear leukocytesB. burgdorferiGranule-poor cytoplastsBorrelia burgdorferiBlood polymorphonuclear leukocytesHuman blood polymorphonuclear leukocytesNumerous polymorphonuclear leukocytesPotent bacteriostatic agentHuman polymorphonuclear leukocytesU-CytAcute inflammationCalprotectinModulatory roleLyme spirocheteLyme diseaseSpecific antibodiesProtein calprotectinBurgdorferiLeukocytesAbundant cytosolic proteinOxidative mechanismsBacteriostatic agentRegrowth assaysQuantitative microscopicInflammation
1992
Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes.
Malawista SE, Montgomery RR, van Blaricom G. Evidence for reactive nitrogen intermediates in killing of staphylococci by human neutrophil cytoplasts. A new microbicidal pathway for polymorphonuclear leukocytes. Journal Of Clinical Investigation 1992, 90: 631-636. PMID: 1379614, PMCID: PMC443143, DOI: 10.1172/jci115903.Peer-Reviewed Original ResearchConceptsReactive nitrogen intermediatesL-arginineNitric oxide synthase inhibitor NGranule-poor cytoplastsKilling of staphylococciNitrogen intermediatesSynthase inhibitor NEffect of NMMAChronic granulomatous diseaseHuman blood neutrophilsHuman neutrophil cytoplastsBlood neutrophilsGranulomatous diseasePolymorphonuclear leukocytesD-arginineIntact PMNsNeutrophil cytoplastsMicrobicidal pathwaysNMMASusceptible targetsMin of incubationModest decreaseInhibitor NStaphylococciOxidase activity