1998
Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse
Watson M, Zinn A, Inoue N, Hess K, Cobb J, Handel M, Halaban R, Duchene C, Albright G, Moreadith R. Identification of morc (microrchidia), a mutation that results in arrest of spermatogenesis at an early meiotic stage in the mouse. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 14361-14366. PMID: 9826705, PMCID: PMC24378, DOI: 10.1073/pnas.95.24.14361.Peer-Reviewed Original ResearchConceptsMammalian germ cell developmentGerm cellsGerm cell developmentNovel biochemical pathwaysEarly meiotic stagesTransgene expressionMale gametogenesisMouse strain transgenicGenomic analysisProphase IMutant animalsTransgene insertionCDNA constructsEye pigmentationBiochemical pathwaysLeptotene stageAbnormal phenotypeCell developmentMeiotic stagesMeiosisMutation resultsArrest of spermatogenesisGenesSpermatogenesisMutations
1990
Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity.
Halaban R, Moellmann G. Murine and human b locus pigmentation genes encode a glycoprotein (gp75) with catalase activity. Proceedings Of The National Academy Of Sciences Of The United States Of America 1990, 87: 4809-4813. PMID: 1693779, PMCID: PMC54207, DOI: 10.1073/pnas.87.12.4809.Peer-Reviewed Original ResearchConceptsPigmentation genesRapid proteolytic degradationMelanosomal glycoproteinLocus proteinBrown locusCatalase BB mutationsProteolytic degradationB locusMelanogenic activityGenesMelanin precursorsLociProteinMutationsGlycoproteinCatalase activityTyrosinaseHydrogen peroxideHydroperoxidaseMelanogenesisGp75ActivityMurinePigmentation
1989
Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment.
Dotto G, Moellmann G, Ghosh S, Edwards M, Halaban R. Transformation of murine melanocytes by basic fibroblast growth factor cDNA and oncogenes and selective suppression of the transformed phenotype in a reconstituted cutaneous environment. Journal Of Cell Biology 1989, 109: 3115-3128. PMID: 2556408, PMCID: PMC2115972, DOI: 10.1083/jcb.109.6.3115.Peer-Reviewed Original ResearchConceptsBasic fibroblast growth factorMurine melanocytesTransformation of melanocytesNormal murine melanocytesMetastatic melanoma cellsSynthesis of melaninMelanotic phenotypeConstitutive expressionFibroblast growth factorOncogene MYCRespective transformantsTransformantsFactor cDNAFormation of tumorsReconstitution experimentsDifferentiated functionsRecombinant retrovirusExogenous basic fibroblast growth factorOncogeneAutonomous growthExpression of bFGFCDNAConstitutive productionNude miceMelanocytes
1987
Normal murine melanocytes in culture
Tamura A, Halaban R, Moellmann G, Cowan J, Lerner M, Lerner A. Normal murine melanocytes in culture. In Vitro Cellular & Developmental Biology 1987, 23: 519-522. PMID: 3610949, DOI: 10.1007/bf02628423.Peer-Reviewed Original Research