1996
Growth factors and melanomas.
Halaban R. Growth factors and melanomas. Seminars In Oncology 1996, 23: 673-81. PMID: 8970586.Peer-Reviewed Original ResearchMeSH KeywordsCarrier ProteinsCell Cycle ProteinsCell Transformation, NeoplasticCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent KinasesEndothelinsFibroblast Growth Factor 2Gene Expression Regulation, NeoplasticGrowth SubstancesHumansMelanocytesMelanomaReceptors, Growth FactorSignal TransductionConceptsCyclin-dependent kinasesFibroblast growth factorNormal human melanocytesMast/stem cell growth factorCell cycleCDK inhibitor p16INK4Human melanocytesMelanoma cellsGrowth factorHepatocyte growth factor/scatter factorStem cell growth factorGrowth factor/scatter factorSynergistic growth factorsNeuropeptide endothelin-1Cell cycle progressionPhosphorylation of retinoblastomaGrowth constraintsWild-type p53Unregulated expressionTranscriptional activityNegative regulatorCycle progressionResult of inactivationBasic fibroblast growth factorInhibitory complex
1995
VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells*
Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi B, Neufeld G. VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells*. Journal Of Biological Chemistry 1995, 270: 11322-11326. PMID: 7744769, DOI: 10.1074/jbc.270.19.11322.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBinding SitesCell DivisionCell LineCell MembraneCross-Linking ReagentsEndothelial Growth FactorsGene ExpressionGenetic VariationHeparinHeparitin SulfateHumansKineticsLymphokinesMelanomaReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, MitogenReceptors, Vascular Endothelial Growth FactorRNA, MessengerTumor Cells, CulturedVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsHuman melanoma cellsVEGF receptorsMelanoma cellsCell surface heparan sulfateVEGF receptor Flt-1VEGF receptor KDR/flkVascular endothelial growth factor isoformsHeparan sulfateReceptor KDR/flkReceptor Flt-1Growth factor isoformsCell surface heparin-like moleculesKDR/FlkVascular endothelial growth factor (VEGF) splice variantsHeparin-like moleculesAddition of heparin
1994
Signal Transduction in Normal and Malignant Melanocytes
HALABAN R. Signal Transduction in Normal and Malignant Melanocytes. Pigment Cell & Melanoma Research 1994, 7: 89-95. PMID: 8066025, DOI: 10.1111/j.1600-0749.1994.tb00026.x.Peer-Reviewed Original ResearchGrowth SubstancesHumansMelanocytesMelanomaModels, BiologicalReceptors, Growth FactorSignal Transduction