2011
In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma
Karreth FA, Tay Y, Perna D, Ala U, Tan SM, Rust AG, DeNicola G, Webster KA, Weiss D, Perez-Mancera PA, Krauthammer M, Halaban R, Provero P, Adams DJ, Tuveson DA, Pandolfi PP. In Vivo Identification of Tumor- Suppressive PTEN ceRNAs in an Oncogenic BRAF-Induced Mouse Model of Melanoma. Cell 2011, 147: 382-395. PMID: 22000016, PMCID: PMC3236086, DOI: 10.1016/j.cell.2011.09.032.Peer-Reviewed Original ResearchConceptsMicroRNA recognition elementsLow PTEN levelsPTEN protein levelsZEB2 expressionBeauty insertional mutagenesisMicroRNA decoysPI3K/Akt pathwayLoss of PTENCeRNA activityInsertional mutagenesisZeb2 transcriptTumor suppressorCell transformationCeRNAsPTEN levelsAkt pathwayFunctional roleMRNA transcriptsSignificant enrichmentZEB2 mRNAProtein levelsMouse modelCeRNATranscriptsPTEN
2010
A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma
Godshalk SE, Paranjape T, Nallur S, Speed W, Chan E, Molinaro AM, Bacchiocchi A, Hoyt K, Tworkoski K, Stern DF, Sznol M, Ariyan S, Lazova R, Halaban R, Kidd KK, Weidhaas JB, Slack FJ. A Variant in a MicroRNA complementary site in the 3′ UTR of the KIT oncogene increases risk of acral melanoma. Oncogene 2010, 30: 1542-1550. PMID: 21119596, PMCID: PMC3069149, DOI: 10.1038/onc.2010.536.Peer-Reviewed Original ResearchConceptsMessenger RNAsComplementary sitesNovel genetic markersKIT oncogeneTarget genesRegulatory relationshipsUntranslated regionGenetic markersHeritable riskFunctional variantsGenetic variantsOncogeneMultifaceted roleProtein levelsProtein expressionVariant resultsComplementary sequencesReporter dataUTRMelanoma pathogenesisMiR-221KIT variantsSeed regionExpressionVariants
1997
Regulation of fibroblast growth factor 2 expression in melanoma cells by the c-MYB proto-oncoprotein.
Miglarese M, Halaban R, Gibson N. Regulation of fibroblast growth factor 2 expression in melanoma cells by the c-MYB proto-oncoprotein. Molecular Cancer Research 1997, 8: 1199-210. PMID: 9372243.Peer-Reviewed Original ResearchConceptsFGF-2 promoterMurine c-MybSK-MEL-2 human melanoma cellsC-MybFunctional DNA-binding domainHuman melanoma cellsDNA-binding domainMelanoma cellsAutocrine growthPutative MybC-myb mRNATranscription factorsEctopic expressionPromoter regionFibroblast growth factorBasic fibroblast growth factorMelanoma cell linesReporter plasmidNormal melanocytesFibroblast growth factor-2 expressionPromoterGrowth factor 2 expressionMYBFGF-2 proteinCell lines
1995
VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells*
Cohen T, Gitay-Goren H, Sharon R, Shibuya M, Halaban R, Levi B, Neufeld G. VEGF121, a Vascular Endothelial Growth Factor (VEGF) Isoform Lacking Heparin Binding Ability, Requires Cell-surface Heparan Sulfates for Efficient Binding to the VEGF Receptors of Human Melanoma Cells*. Journal Of Biological Chemistry 1995, 270: 11322-11326. PMID: 7744769, DOI: 10.1074/jbc.270.19.11322.Peer-Reviewed Original ResearchMeSH KeywordsAlternative SplicingBinding SitesCell DivisionCell LineCell MembraneCross-Linking ReagentsEndothelial Growth FactorsGene ExpressionGenetic VariationHeparinHeparitin SulfateHumansKineticsLymphokinesMelanomaReceptor Protein-Tyrosine KinasesReceptors, Growth FactorReceptors, MitogenReceptors, Vascular Endothelial Growth FactorRNA, MessengerTumor Cells, CulturedVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsHuman melanoma cellsVEGF receptorsMelanoma cellsCell surface heparan sulfateVEGF receptor Flt-1VEGF receptor KDR/flkVascular endothelial growth factor isoformsHeparan sulfateReceptor KDR/flkReceptor Flt-1Growth factor isoformsCell surface heparin-like moleculesKDR/FlkVascular endothelial growth factor (VEGF) splice variantsHeparin-like moleculesAddition of heparin
1993
KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells.
Zakut R, Perlis R, Eliyahu S, Yarden Y, Givol D, Lyman S, Halaban R. KIT ligand (mast cell growth factor) inhibits the growth of KIT-expressing melanoma cells. Oncogene 1993, 8: 2221-9. PMID: 7687762.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceCell DivisionHematopoietic Cell Growth FactorsHumansMelanomaMolecular Sequence DataNeoplasm ProteinsPhosphorylationProtein-Tyrosine KinasesProto-Oncogene MasProto-Oncogene ProteinsProto-Oncogene Proteins c-kitRNA, MessengerRNA, NeoplasmStem Cell FactorTumor Cells, CulturedConceptsMast cell growth factorMelanoma cell linesNormal melanocyte developmentMelanoma cellsAberrant signal transductionMetastatic melanoma cell linesCell linesActivation of KITMelanocyte developmentSignal transductionKIT proto-oncogeneKinase activationKIT mRNAKit ligandNormal melanocytesProto-oncogeneKIT kinaseCell growth factorBiological responsesGrowth factorHuman melanomaMelanocytesCellsKIT expressionNeoplastic melanocytesAltered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis
Longley B, Morganroth G, Tyrrell L, Ding T, Anderson D, Williams D, Halaban R. Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis. New England Journal Of Medicine 1993, 328: 1302-1307. PMID: 7682288, DOI: 10.1056/nejm199305063281803.Peer-Reviewed Original ResearchConceptsMast cell growth factorMessenger RNAGrowth factorC-kit proto-oncogeneProduction of melaninSoluble formGrowth factor geneFactor genesProteolytic processingProto-oncogeneSequence abnormalitiesExtracellular spaceAltered metabolismAltered distributionGrowth factor messenger RNASkin of patientsDermal cellsCellsPolymerase chain reactionCutaneous mastocytosisMast cells
1991
Localization of Basic Fibroblast Growth Factor mRNA in Melanocytic Lesions by In Situ Hybridization
Scott G, Stoler M, Sarkar S, Halaban R. Localization of Basic Fibroblast Growth Factor mRNA in Melanocytic Lesions by In Situ Hybridization. Journal Of Investigative Dermatology 1991, 96: 318-322. PMID: 2002252, DOI: 10.1111/1523-1747.ep12465203.Peer-Reviewed Original ResearchMeSH KeywordsFibroblast Growth Factor 2HumansMelanocytesMelanomaNucleic Acid HybridizationRNA, MessengerSkin NeoplasmsConceptsBFGF gene transcriptsBasic fibroblast growth factorGene transcriptsCell populationsGrowth factorNormal human melanocytesDermal cell typesFibroblast growth factorHuman melanocytesCell typesParacrine growth factorCellular proliferationAberrant expressionSitu hybridizationMelanocytic lesionsMetastatic melanomaBasic FGF expressionFGF expressionGrowth independenceTranscriptsBasic fibroblast growth factor mRNADysplastic neviExpressionParacrine mechanismsMelanocytes
1988
Cloning and characterization of a human tyrosinase cDNA.
Kwon B, Haq A, Kim G, Pomerantz S, Halaban R. Cloning and characterization of a human tyrosinase cDNA. Progress In Clinical And Biological Research 1988, 256: 273-82. PMID: 2835779.Peer-Reviewed Original Research