1996
Growth Regulatory Proteins that Repress Differentiation Markers in Melanocytes Also Downregulate the Transcription Factor Microphthalmia
Halaban R, Böhm M, Dotto P, Moellmann G, Cheng E, Zhang Y. Growth Regulatory Proteins that Repress Differentiation Markers in Melanocytes Also Downregulate the Transcription Factor Microphthalmia. Journal Of Investigative Dermatology 1996, 106: 1266-1272. PMID: 8752668, DOI: 10.1111/1523-1747.ep12348972.Peer-Reviewed Original ResearchConceptsTranscription factorsFibroblast growth factorBasic fibroblast growth factorMelanocyte-specific genesMelanogenic gene expressionTranscription factor microphthalmiaDownregulated transcription factorsDNA consensus siteTyrosinase-related protein 1Human metastatic melanoma cellsImmortalized mouse melanocytesPink-eyed dilutionCloudman S91 mouse melanomaMetastatic melanoma cellsSequestration of p300Transcriptional adaptorGrowth factorE1A mutantsConsensus sitesMouse melanocytesRegulatory proteinsMolecular basisOncogene RasGene expressionTumorigenic transformation
1993
White Mutants in Mice Shedding Light on Humans
Halaban R, Moellmann G. White Mutants in Mice Shedding Light on Humans. Journal Of Investigative Dermatology 1993, 100: s176-s185. DOI: 10.1038/jid.1993.73.Peer-Reviewed Original ResearchMembrane receptor tyrosine kinasesMouse mutant modelsPink-eyed dilutionDefective signal transductionReceptor kinase activityEnzyme activityC-kitDistinct enzyme activitiesIdentification of mutationsRespective enzyme activitiesPiebald phenotypeShares homologyLocus proteinSignal transductionKinase activityCatalase BMolecular geneticsTyrosine kinaseWhite mutantsMutant modelsHair melanocytesPoint mutationsTyrosinase-negative albinismNormal pigmentationProliferation of melanocytesWhite mutants in mice shedding light on humans.
Halaban R, Moellmann G. White mutants in mice shedding light on humans. Journal Of Investigative Dermatology 1993, 100: 176s-185s. PMID: 8433006, DOI: 10.1038/jid.1993.10.Peer-Reviewed Original ResearchConceptsMembrane receptor tyrosine kinasesMouse mutant modelsPink-eyed dilutionDefective signal transductionReceptor kinase activityEnzyme activityC-kitDistinct enzyme activitiesIdentification of mutationsRespective enzyme activitiesPiebald phenotypeShares homologyLocus proteinSignal transductionKinase activityCatalase BMolecular geneticsTyrosine kinaseWhite mutantsMutant modelsHair melanocytesDopachrome tautomerasePoint mutationsTyrosinase-negative albinismNormal pigmentation