1997
Chymase cleavage of stem cell factor yields a bioactive, soluble product
Longley B, Tyrrell L, Ma Y, Williams D, Halaban R, Langley K, Lu H, Schechter N. Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 9017-9021. PMID: 9256427, PMCID: PMC23007, DOI: 10.1073/pnas.94.17.9017.Peer-Reviewed Original ResearchConceptsSoluble SCFCell factorMembrane-bound moleculesMast cell secretory granulesStromal cellsStem cell factorChymotrypsin-like proteaseSCF geneCell secretory granulesC-terminusPossible feedback loopRelevant enzymesNovel siteAmino acidsDifferentiated functionsMast cellsCell proliferationExon 6Secretory granulesHuman mast cell chymaseChronic cutaneous inflammationMast cell chymaseKIT proteinBioactive productsMast cell proliferation
1993
Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis
Longley B, Morganroth G, Tyrrell L, Ding T, Anderson D, Williams D, Halaban R. Altered Metabolism of Mast-Cell Growth Factor (c-kit Ligand) in Cutaneous Mastocytosis. New England Journal Of Medicine 1993, 328: 1302-1307. PMID: 7682288, DOI: 10.1056/nejm199305063281803.Peer-Reviewed Original ResearchConceptsMast cell growth factorMessenger RNAGrowth factorC-kit proto-oncogeneProduction of melaninSoluble formGrowth factor geneFactor genesProteolytic processingProto-oncogeneSequence abnormalitiesExtracellular spaceAltered metabolismAltered distributionGrowth factor messenger RNASkin of patientsDermal cellsCellsPolymerase chain reactionCutaneous mastocytosisMast cells