2008
Metastatic Peritoneal Neurocutaneous Melanocytosis
Cajaiba MM, Benjamin D, Halaban R, Reyes-Múgica M. Metastatic Peritoneal Neurocutaneous Melanocytosis. The American Journal Of Surgical Pathology 2008, 32: 156-161. PMID: 18162783, DOI: 10.1097/pas.0b013e3181238cd2.Peer-Reviewed Original ResearchConceptsNeurocutaneous melanocytosisCentral nervous systemComplex cytogenetic rearrangementsSevere neurologic manifestationsVentriculo-peritoneal shuntingPrimary skin melanomaLarge congenital melanocytic neviAtypical cell proliferationCongenital melanocytic neviSpecific diagnostic criteriaRare congenital disorderCNS metastasesNeurologic manifestationsNeurologic symptomsClinical courseLesion variesHistopathologic featuresNeurocutaneous melanosisBiologic featuresMalignant melanomaPeritoneal surfaceAggressive phenotypeDiagnostic criteriaNervous systemProliferation of melanocytes
2004
Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome
Berger AJ, Camp RL, DiVito KA, Kluger HM, Halaban R, Rimm DL. Automated Quantitative Analysis of HDM2 Expression in Malignant Melanoma Shows Association with Early-Stage Disease and Improved Outcome. Cancer Research 2004, 64: 8767-8772. PMID: 15574789, DOI: 10.1158/0008-5472.can-04-1384.Peer-Reviewed Original ResearchConceptsMurine double minute 2Double minute 2Protein expressionMalignant melanomaMinute 2Early-stage diseaseTissue microarray cohortPotential tissue biomarkersCutaneous malignant melanomaValuable prognostic toolNormal skin samplesSkin cancer deathsMicroarray cohortAdvanced melanomaMetastatic lesionsCancer deathPrimary melanomaImproved outcomesExpression of HDM2Tissue biomarkersPrognostic toolBetter outcomesMelanoma lesionsAggressive natureMelanoma
1991
Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes.
Ramon y Cajal S, Suster S, Halaban R, Filvaroff E, Dotto G. Induction of different morphologic features of malignant melanoma and pigmented lesions after transformation of murine melanocytes with bFGF-cDNA and H-ras, myc, neu, and E1a oncogenes. American Journal Of Pathology 1991, 138: 349-58. PMID: 1992762, PMCID: PMC1886204.Peer-Reviewed Original ResearchConceptsMalignant tumorsMorphologic featuresDifferent morphologic featuresMalignant melanomaBenign lesionsNude miceSyngenic miceSame tumorMelanocytic lesionsSmall round cellsBasic fibroblast growth factorH-RasFibroblast growth factorBenign melanocytic lesionsHistologic typeHistologic featuresSubcutaneous injectionBiologic behaviorSpindle cellsPossible molecular mechanismsEpithelioid cellsIntradermal nevusHuman melanomaLesionsDifferent tumors
1985
Primary Melanoma Cells of the Vertical Growth Phase: Similarities to Metastatic Cells2
Herlyn M, Balaban G, Bennicelli J, Guerry D, Halaban R, Herlyn D, Elder D, Maul G, Steplewski Z, Nowell P, Clark W, Koprowski H. Primary Melanoma Cells of the Vertical Growth Phase: Similarities to Metastatic Cells2. Journal Of The National Cancer Institute 1985, 74: 283-289. PMID: 3856042, DOI: 10.1093/jnci/74.2.283.Peer-Reviewed Original ResearchConceptsVertical growth phaseMetastatic melanoma cellsMelanoma cellsMetastatic lesionsPrimary melanomaMetastatic cellsMelanoma-associated antigensMixed hemadsorption assaysPrimary melanoma cellsLong-term cultured cellsMetastatic melanoma cell linesGrowth phaseMelanoma cell linesRadial growth phaseMalignant melanomaNude micePopulation-doubling timeNonrandom abnormalitiesFlow cytometryHemadsorption assaysMonoclonal antibodiesMelanomaPatientsCell linesLesions