1997
Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells
Halaban R, Cheng E, Zhang Y, Moellmann G, Hanlon D, Michalak M, Setaluri V, Hebert D. Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 6210-6215. PMID: 9177196, PMCID: PMC21028, DOI: 10.1073/pnas.94.12.6210.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcium-Binding ProteinsCalnexinCalreticulinCell DifferentiationCells, CulturedCoculture TechniquesEndoplasmic ReticulumEnzyme PrecursorsHumansInfant, NewbornKineticsMelanocytesMelanomaMolecular ChaperonesMolecular WeightMonophenol MonooxygenasePhenotypeRibonucleoproteinsSkin NeoplasmsTime FactorsTumor Cells, CulturedConceptsEndoplasmic reticulumNormal melanocytesER chaperone calnexinMelanin synthesisMalignant melanocytesMelanoma cellsChaperone bindingAberrant retentionChaperone calnexinGolgi compartmentSubcellular localizationAmelanotic melanoma cell lineKey enzymeMelanoma cell linesMaturation of tyrosinaseAmelanotic melanoma cellsKinetics of synthesisInhibitor sensitivityDedifferentiated phenotypeProteolytic degradationCell linesProteasome inhibitorsEnzymeProteasomeImmature forms
1993
A transcriptional inhibitor induced in human melanoma cells upon ultraviolet irradiation.
Yang Y, Rutberg S, Luo F, Spratt T, Halaban R, Ferrone S, Ronai Z. A transcriptional inhibitor induced in human melanoma cells upon ultraviolet irradiation. Molecular Cancer Research 1993, 4: 595-602. PMID: 8398900.Peer-Reviewed Original ResearchHuman Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors
Gitaygoren H, Halaban R, Neufeld G. Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors. Biochemical And Biophysical Research Communications 1993, 190: 702-709. PMID: 8439321, DOI: 10.1006/bbrc.1993.1106.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCross-Linking ReagentsEndothelial Growth FactorsHeparinHumansIn Vitro TechniquesLymphokinesMelanocytesMelanomaProtein-Tyrosine KinasesReceptors, MitogenReceptors, Vascular Endothelial Growth FactorRecombinant ProteinsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorHuman melanoma cellsMelanoma cellsMalignant transformationVEGF receptorsVascular endothelial growth factor receptorEndothelial growth factor receptorNormal melanocytesEndothelial growth factorGrowth factor receptorMelanoma cell linesHeparin-like moleculesAngiogenic factorsEndothelial cellsSpecific mitogenAberrant expressionGrowth factorFactor receptorLigand/receptor interactionsReceptorsMalignant melanocytesRadioactive ligandExogenous heparinPossible involvementReceptor interactionGrowth Regulation in Normal and Malignant Melanocytes
Halaban R. Growth Regulation in Normal and Malignant Melanocytes. Recent Results In Cancer Research 1993, 128: 133-150. PMID: 8356315, DOI: 10.1007/978-3-642-84881-0_10.Peer-Reviewed Original ResearchConceptsNormal human melanocytesHuman melanocytesSignal transduction pathwaysGrowth factorMalignant melanocytesGrowth factors/receptorsTransduction pathwaysGrowth regulationConstitutive activationBiochemical basisBiochemical eventsNormal melanocytesGrowth phaseRadial growth phaseMalignant stateMelanocytesMelanoma cellsNormal counterpartsPreneoplastic cellsReceptor activityInappropriate productionCellsMetastatic melanoma lesionsActivationReceptors
1987
Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus.
Kwon BS, Haq AK, Pomerantz SH, Halaban R. Isolation and sequence of a cDNA clone for human tyrosinase that maps at the mouse c-albino locus. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 7473-7477. PMID: 2823263, PMCID: PMC299318, DOI: 10.1073/pnas.84.21.7473.Peer-Reviewed Original ResearchConceptsCDNA clonesMelanocyte cDNA libraryRelated mRNA speciesHuman tyrosinaseAmino acid sequenceSouthern blot analysisStructural geneCDNA libraryNucleotide sequenceMRNA speciesAcid sequenceGlycosylation sitesCDNA insertDeletion mutationsCell typesAmino acidsCopper bindingBlot analysisClonesMalignant melanocytesLociSequenceTyrosinaseApproximate lengthKilobases