1992
Growth Factors, Receptor Kinases, and Protein Tyro sine Phosphatases in Normal and Malignant Melanocytes
Halaban R, Fan B, Ahn J, Funasaka Y, Gitay-Goren H, Neufeld G. Growth Factors, Receptor Kinases, and Protein Tyro sine Phosphatases in Normal and Malignant Melanocytes. Journal Of Immunotherapy 1992, 12: 154-161. PMID: 1445804, DOI: 10.1097/00002371-199210000-00002.Peer-Reviewed Original ResearchConceptsMast cell growth factorReceptor tyrosine kinasesFibroblast growth factorTyrosine kinaseTyrosyl-phosphorylated proteinsExpression of pigmentationTransmembrane receptor tyrosine kinaseHepatocyte growth factorGrowth factorGrowth factor/receptor systemsHuman melanocyte proliferationBasic FGFMelanoma cellsProtein tyrosineReceptor kinasePigment cellsBasic fibroblast growth factorFGF receptorsKinaseHuman melanoma cellsNormal melanocytesKIT kinaseMalignant phenotypeMelanocyte proliferationCell growth factorScatter factor and hepatocyte growth factor: activities, properties, and mechanism.
Bhargava M, Joseph A, Knesel J, Halaban R, Li Y, Pang S, Goldberg I, Setter E, Donovan M, Zarnegar R. Scatter factor and hepatocyte growth factor: activities, properties, and mechanism. Molecular Cancer Research 1992, 3: 11-20. PMID: 1534687.Peer-Reviewed Original ResearchConceptsHepatocyte growth factorScatter factorPartial amino acid sequence dataAmino acid sequence dataAmino acid sequenceFibroblast-derived proteinHuman smooth muscle cellsVascular endothelial cell typesEndothelial cell typesGrowth factorSignificant homologyPosttranslational modificationsSequence dataRapid phosphorylationAcid sequenceBiological activityTyrosine residuesProtein productsCohesive coloniesCommon antigenic determinantsCell typesSpecies-related differencesProteinSerum-derived proteinsHuman hepatocyte growth factor
1991
Growth factors and tyrosine protein kinases in normal and malignant melanocytes
Halaban R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer And Metastasis Reviews 1991, 10: 129-140. PMID: 1873853, DOI: 10.1007/bf00049410.Peer-Reviewed Original ResearchConceptsMast cell growth factorTyrosine kinase activityKinase activityBasic fibroblast growth factorNormal melanocyte proliferationTyrosine kinaseExogenous peptide growth factorsHepatocyte growth factorGrowth factorTyrosine protein kinaseAberrant gene expressionMelanocyte proliferationTransmembrane tyrosine kinaseReceptor tyrosine kinasesEnvironmental growth factorsNormal human melanocytesPeptide growth factorsMouse melanocytesProtein kinaseGrowth factor receptorUncontrolled growthC-kitGene expressionConstitutive expressionFibroblast growth factor