2006
Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes
Halaban R, Moellmann G. Growth Factor Receptors and Signal Transduction Regulating the Proliferation and Differentiation of Melanocytes. 2006, 445-463. DOI: 10.1002/9780470987100.ch22.Peer-Reviewed Original Research
1993
Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors
Gitaygoren H, Halaban R, Neufeld G. Human Melanoma Cells but Not Normal Melanocytes Express Vascular Endothelial Growth Factor Receptors. Biochemical And Biophysical Research Communications 1993, 190: 702-709. PMID: 8439321, DOI: 10.1006/bbrc.1993.1106.Peer-Reviewed Original ResearchMeSH KeywordsCells, CulturedCross-Linking ReagentsEndothelial Growth FactorsHeparinHumansIn Vitro TechniquesLymphokinesMelanocytesMelanomaProtein-Tyrosine KinasesReceptors, MitogenReceptors, Vascular Endothelial Growth FactorRecombinant ProteinsVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsVascular endothelial growth factorHuman melanoma cellsMelanoma cellsMalignant transformationVEGF receptorsVascular endothelial growth factor receptorEndothelial growth factor receptorNormal melanocytesEndothelial growth factorGrowth factor receptorMelanoma cell linesHeparin-like moleculesAngiogenic factorsEndothelial cellsSpecific mitogenAberrant expressionGrowth factorFactor receptorLigand/receptor interactionsReceptorsMalignant melanocytesRadioactive ligandExogenous heparinPossible involvementReceptor interaction
1991
Growth factors and tyrosine protein kinases in normal and malignant melanocytes
Halaban R. Growth factors and tyrosine protein kinases in normal and malignant melanocytes. Cancer And Metastasis Reviews 1991, 10: 129-140. PMID: 1873853, DOI: 10.1007/bf00049410.Peer-Reviewed Original ResearchConceptsMast cell growth factorTyrosine kinase activityKinase activityBasic fibroblast growth factorNormal melanocyte proliferationTyrosine kinaseExogenous peptide growth factorsHepatocyte growth factorGrowth factorTyrosine protein kinaseAberrant gene expressionMelanocyte proliferationTransmembrane tyrosine kinaseReceptor tyrosine kinasesEnvironmental growth factorsNormal human melanocytesPeptide growth factorsMouse melanocytesProtein kinaseGrowth factor receptorUncontrolled growthC-kitGene expressionConstitutive expressionFibroblast growth factorGrowth factors regulating normal and malignant melanocytes
Halaban R. Growth factors regulating normal and malignant melanocytes. Cancer Treatment And Research 1991, 54: 19-40. PMID: 1673857, DOI: 10.1007/978-1-4615-3938-4_2.Peer-Reviewed Original ResearchConceptsEpidermal growth factorGrowth factor receptorV-erbEGF receptorFactor receptorGrowth factorStimulating factor receptorMacrophage-colony stimulating factor receptorEnvironmental growth factorsNormal human melanocytesRetroviral oncogenesCellular genesMitogenic signalsConstitutive activityHuman melanocytesNontransformed cellsRespective target cellsUnidentified ligandCell membraneGenesAberrant expressionNeoplastic transformationAutocrine loopNormal growthNormal cellsProliferation and malignant transformation of melanocytes.
Halaban R, Moellmann G. Proliferation and malignant transformation of melanocytes. Critical Reviews™ In Oncogenesis 1991, 2: 247-58. PMID: 1958709.Peer-Reviewed Original ResearchConceptsActive receptor tyrosine kinasesTissue-specific genesReceptor tyrosine kinasesSignal transmission pathwaysGrowth factor receptorLow molecular weight inhibitorsUnregulated expressionCertain chromosomesTyrosine kinaseGenesNormal melanocytesMalignant transformationMouse fibroblastsFactor receptorDrug designWeight inhibitorsKaryotypic changesKinaseMelanoma-prone familiesGrowth factorOncogeneHuman melanomaMelanocytesMelanoma growthTransmission pathways