Autoimmune Gastritis Mediated by CD4+ T Cells Promotes the Development of Gastric Cancer
Nguyen T, Khurana S, Bellone C, Capoccia B, Sagartz J, Kesman R, Mills J, DiPaolo R. Autoimmune Gastritis Mediated by CD4+ T Cells Promotes the Development of Gastric Cancer. Cancer Research 2013, 73: 2117-2126. PMID: 23378345, PMCID: PMC3652548, DOI: 10.1158/0008-5472.can-12-3957.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAnimalsAutoimmune DiseasesBlotting, WesternCD4-Positive T-LymphocytesFlow CytometryFluorescent Antibody TechniqueGastric MucosaGastritisH(+)-K(+)-Exchanging ATPaseHumansImmunoenzyme TechniquesInflammationInterferon-gammaLymph NodesMetaplasiaMiceMice, Inbred BALB CMice, TransgenicReal-Time Polymerase Chain ReactionReceptors, Antigen, T-CellReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStomach NeoplasmsConceptsAutoimmune gastritisGastric cancerT cellsChronic inflammationTransgenic T cell receptorCD4(+) T cellsCD4+ T cellsMouse model of autoimmune gastritisDevelopment of gastric neoplasiaSpasmolytic polypeptide-expressing metaplasiaMucous neck cell hyperplasiaProgression of human gastric cancerGastric carcinoid tumorsGastric intraepithelial neoplasiaT cell receptorDevelopment of gastric cancerHuman gastric cancerProgression of gastric cancerIntraepithelial neoplasiaOxyntic atrophyCarcinoid tumorsCell hyperplasiaCell aberrationsGastrointestinal cancerIncreased risk