2020
Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia
Gautam S, Cohen AJ, Stahl Y, Toro P, Young GM, Datta R, Yan X, Ristic NT, Bermejo SD, Sharma L, Restrepo M, Dela Cruz CS. Severe respiratory viral infection induces procalcitonin in the absence of bacterial pneumonia. Thorax 2020, 75: 974-981. PMID: 32826284, DOI: 10.1136/thoraxjnl-2020-214896.Peer-Reviewed Original ResearchConceptsPure viral infectionBacterial coinfectionViral infectionInfluenza infectionSevere respiratory viral infectionsAbility of procalcitoninRetrospective cohort studyViral respiratory infectionsRespiratory viral infectionsMarker of severityRespiratory viral illnessSevere viral infectionsSpecificity of procalcitoninCharacteristic curve analysisCellular modelHigher procalcitoninProcalcitonin expressionElevated procalcitoninCohort studyViral illnessRespiratory infectionsAntibiotic administrationBacterial pneumoniaSevere diseaseProcalcitonin
2010
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB. Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. Journal Of Clinical Investigation 2010, 120: 3220-3233. PMID: 20739753, PMCID: PMC2929724, DOI: 10.1172/jci42748.Peer-Reviewed Original ResearchConceptsS. aureus infectionPoly-N-acetyl glucosamineAureus infectionOpsonic killingCapsular polysaccharideNew prophylactic approachS. aureus bacteremiaCommunity-acquired infectionsStaphylococcus aureus antigenOPK activityAureus bacteremiaProtective immunityComplement depositionEffective immunityProphylactic approachMouse modelSuch antigensVaccine componentsIdiotype interactionsHuman immunityAnimal antiseraGram-positive bacterial pathogensHuman antibodiesInfectionMonoclonal antibodies