2018
Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation
Karnik R, Uppu SC, Tozzi M, Doucette J, Lytrivi ID, Geiger M, Klas B, Parness IA, Shenoy R, Rajagopal H, Srivastava S. Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation. Pediatric Cardiology 2018, 39: 1172-1180. PMID: 29644405, DOI: 10.1007/s00246-018-1877-9.Peer-Reviewed Original ResearchConceptsRight ventricular dilationRV dilationAbnormal ARLV systolicPulmonary regurgitationVentricular dilationRotational mechanicsApical rotationYoung childrenAge-matched normal controlsAsymptomatic young childrenLeft ventricular dysfunctionSingle-center studyLV myocardial mechanicsTetralogy of FallotLV rotational mechanicsTwo-dimensional echocardiographyFurther longitudinal studiesLeft ventricular rotationRTOF childrenLack of maturationVentricular dysfunctionDiastolic dysfunctionDiastolic functionClinical outcomes
2014
Cardiotoxicity and Cardioprotection in Childhood Cancer
Lipshultz SE, Sambatakos P, Maguire M, Karnik R, Ross SW, Franco VI, Miller TL. Cardiotoxicity and Cardioprotection in Childhood Cancer. Acta Haematologica 2014, 132: 391-399. PMID: 25228565, DOI: 10.1159/000360238.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnthracycline cumulative doseAdverse late effectsSignificant cardiovascular diseaseUse of dexrazoxaneLong-term cardioprotectionAnthracycline chemotherapyCardiovascular damageCardioprotective strategiesOncological efficacyCardiac damageBlack raceCumulative doseFemale sexRisk factorsChildhood cancerCardiotoxic effectsCardiovascular diseaseLate effectsHigh riskHigh doseGenetic predispositionCardiotoxicityYounger ageTrisomy 21Nutritional supplements