2004
Potential role of molecularly targeted therapy in the management of advanced nonsmall cell lung carcinoma in the elderly
Gridelli C, Massarelli E, Maione P, Rossi A, Herbst RS, Onn A, Ciardiello F. Potential role of molecularly targeted therapy in the management of advanced nonsmall cell lung carcinoma in the elderly. Cancer 2004, 101: 1733-1744. PMID: 15386339, DOI: 10.1002/cncr.20572.Peer-Reviewed Original ResearchConceptsAdvanced nonsmall cell lung carcinomaNonsmall cell lung carcinomaNovel biologic agentsElderly patientsCell lung carcinomaConventional chemotherapyPatient ageBiologic agentsLung carcinomaClinical developmentSuch elderly patientsVascular endothelial growth factorLung carcinoma casesQuality of lifeEndothelial growth factorEpidermal growth factor receptorGrowth factor receptorAggressive chemotherapyImproved tolerabilityYounger patientsOrgan failureTherapy regimensComorbid conditionsMalignant diseaseCarcinoma cases
2000
Vinorelbine and Gemcitabine Combinations in Advanced Non–Small-Cell Lung Cancer
Lilenbaum R, Herbst R. Vinorelbine and Gemcitabine Combinations in Advanced Non–Small-Cell Lung Cancer. Clinical Lung Cancer 2000, 2: 123-127. PMID: 14731322, DOI: 10.3816/clc.2000.n.024.Peer-Reviewed Original ResearchAdvanced non-small cell lung cancerNon-small cell lung cancerLung cancerSmall cell lung cancerPoor performance statusTaxane-based regimensVinorelbine/gemcitabinePlatinum-based regimensSingle-agent activityTreatment of patientsOverall response rateNew chemotherapeutic agentsNonoverlapping toxicitiesGemcitabine combinationElderly patientsPerformance statusRandomized studyResponse rateWeekly scheduleChemotherapeutic agentsVinorelbineRegimensGemcitabinePatientsRegimen