Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients
Suleiman A, Santer P, Munoz-Acuna R, Hammer M, Schaefer MS, Wachtendorf LJ, Rumyantsev S, Berra L, Chamadia S, Johnson-Akeju O, Baedorf-Kassis EN, Eikermann M. Effects of Ketamine Infusion on Breathing and Encephalography in Spontaneously Breathing ICU Patients. Journal Of Intensive Care Medicine 2022, 38: 299-306. PMID: 35934953, DOI: 10.1177/08850666221119716.Peer-Reviewed Original ResearchConceptsSpontaneous breathing trialKetamine infusionMcg/Inspiratory flowInspiratory workKey secondary endpointProspective interventional studyEnd-expiratory pressurePre-specified time pointsKetamine 10Breathing trialSecondary endpointsPrimary outcomeICU patientsIll patientsMechanical ventilationEsophageal pressureInfusion regimenInterventional studyPropofol sedationRespiratory timingResistive workAirway flowPreclinical studiesElectroencephalographic patterns