2000
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
Herrick C, MacLeod H, Glusac E, Tigelaar R, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Journal Of Clinical Investigation 2000, 105: 765-775. PMID: 10727445, PMCID: PMC377464, DOI: 10.1172/jci8624.Peer-Reviewed Original ResearchConceptsTh2 responsesIL-13IL-4Th2-type immune responseIL-4-deficient miceTh2-promoting cytokinesOVA-specific IgG1Bronchoalveolar lavage fluidWild-type miceAllergen encounterTh2 sensitizationAirway challengeTh2 activationAllergen exposureAtopic individualsBAL fluidEnvironmental allergensWT miceLavage fluidPrimary exposureVivo depletionAnatomic sitesImmune responseAnimal modelsMice
1995
Immunobiology of Mouse Dendritic Epidermal T Cells: A Decade Later, Some Answers, But Still More Questions
Tigelaar R, Lewis J. Immunobiology of Mouse Dendritic Epidermal T Cells: A Decade Later, Some Answers, But Still More Questions. Journal Of Investigative Dermatology 1995, 105: s43-s49. DOI: 10.1038/jid.1995.9.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDendritic epidermal T cellsEpidermal T cellsT cell receptorΓδ cellsT cellsMouse dendritic epidermal T-cellsMurine dendritic epidermal T cellsCutaneous immune surveillanceNormal human skinSelf antigensImmune surveillanceNormal miceActive hair growthAdult miceEpithelial sitesCutaneous physiologyReproductive tractTissue restrictionHair growthFunctional activityMiceSkinHuman skinReceptorsOverwhelming evidenceImmunobiology of mouse dendritic epidermal T cells: a decade later, some answers, but still more questions.
Tigelaar R, Lewis J. Immunobiology of mouse dendritic epidermal T cells: a decade later, some answers, but still more questions. Journal Of Investigative Dermatology 1995, 105: 43s-49s. PMID: 7615996, DOI: 10.1111/1523-1747.ep12315280.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDendritic epidermal T cellsEpidermal T cellsGamma delta cellsT cell receptorT cellsMouse dendritic epidermal T-cellsMurine dendritic epidermal T cellsDelta T-cell receptorCutaneous immune surveillanceDelta cellsAlpha beta cellsNormal human skinSelf antigensImmune surveillanceNormal miceActive hair growthAdult miceBeta cellsEpithelial sitesCutaneous physiologyReproductive tractTissue restrictionHair growthFunctional activityMice
1990
TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue
Tigelaar R, Lewis J, Bergstresser P. TCR γ/δ+ Dendritic Epidermal T Cells as Constituents of Skin-Associated Lymphoid Tissue. Journal Of Investigative Dermatology 1990, 94: s58-s63. PMID: 1972173, DOI: 10.1111/1523-1747.ep12875138.Peer-Reviewed Original ResearchConceptsDendritic epidermal T cellsGamma/delta cellsT cell antigen receptorEpidermal T cellsT cellsCD4-CD8Alpha/beta T cell antigen receptorGamma/delta typeSkin-Associated Lymphoid TissueBone marrow-derived cellsGamma/delta populationsClass II MHC moleculesDelta cellsMarrow-derived cellsTCR junctional regionsEarly fetal thymocytesMHC-like moleculesLangerhans cellsLymphoid tissueTCR heterogeneityNormal miceMHC moleculesThy-1Fetal thymocytesMHC type