1990
Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions.
Girolomoni G, Tigelaar R. Capsaicin-sensitive primary sensory neurons are potent modulators of murine delayed-type hypersensitivity reactions. The Journal Of Immunology 1990, 145: 1105-12. PMID: 2380551, DOI: 10.4049/jimmunol.145.4.1105.Peer-Reviewed Original ResearchConceptsDelayed-type hypersensitivity reactionPrimary sensory neuronsHypersensitivity reactionsSensory neuronsCapsaicin-sensitive primary sensory neuronsBALB/c miceCapsaicin-pretreated miceEffector T cellsContact sensitivity reactionAdoptive transfer experimentsCutaneous inflammatory reactionsTopical capsaicinCapsaicin pretreatmentNeurogenic inflammationC miceNeuropeptide releaseHistologic studyInflammatory reactionT cellsPeptidergic neuronsIrritant reactionsSensitivity reactionsSuch neuronsCapsaicinPotent modulator
1985
Lymphocyte Traffic and the Skin
Tigelaar R. Lymphocyte Traffic and the Skin. Dermatologic Clinics 1985, 3: 569-585. PMID: 3916171, DOI: 10.1016/s0733-8635(18)30857-x.Peer-Reviewed Original ResearchConceptsPeripheral lymph nodesLymph nodesLymphocyte migrationEndothelial cellsLymphoid organsImmunologic influenceMesenteric lymph nodesMovement of lymphocytesLymphocyte membrane receptorsDifferent organ sitesSpecialized endothelial cellsNonlymphoid organsLymphocyte trafficImmunologic defenseT cellsGastrointestinal tractOrgan sitesBlast transformationMajor subsetSkinLymphocytesCommon determinantsOrgansMembrane receptorsCells
1983
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.
Elmets C, Bergstresser P, Tigelaar R, Wood P, Streilein J. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal Of Experimental Medicine 1983, 158: 781-794. PMID: 6193234, PMCID: PMC2187099, DOI: 10.1084/jem.158.3.781.Peer-Reviewed Original ResearchConceptsTolerogenic signalsLow-dose ultraviolet B (UVB) radiationLow-dose ultraviolet radiationAntigen-presenting potentialAntigen-specific unresponsivenessResident Langerhans cellsMechanism of unresponsivenessSuppressor cellsContact hypersensitivityLyt-1Effector stageLangerhans cellsSystemic administrationT cellsLocal applicationUltraviolet B radiationInduction phaseB radiationUnresponsivenessSkinUltraviolet radiationCellsTolerogenDNFBHypersensitivityContact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies.
Ray M, Tharp M, Sullivan T, Tigelaar R. Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies. The Journal Of Immunology 1983, 131: 1096-102. PMID: 6193174, DOI: 10.4049/jimmunol.131.3.1096.Peer-Reviewed Original ResearchConceptsContact hypersensitivity reactionHypersensitivity reactionsDNFB challengeUnsensitized controlsAntigen challengeReactive haptenMonoclonal IgE anti-DNP antibodyIgE anti-DNP antibodyIgE anti-hapten antibodyBALB/c miceAllergic contact dermatitis reactionsBiphasic patternIgE-sensitized miceEars of miceCutaneous hypersensitivity reactionsCutaneous hypersensitivity responseCutaneous inflammatory reactionsContact dermatitis reactionsFailure of miceAnti-hapten antibodiesAnti-DNP antibodiesEar challengeEar swellingHypersensitivity responseIgE antibodies
1973
SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1973, 137: 239-253. PMID: 4405532, PMCID: PMC2139477, DOI: 10.1084/jem.137.2.239.Peer-Reviewed Original ResearchConceptsThymus-derived cellsAdult syngeneic recipientsAnti-theta antibodyPeripheral lymph nodesNormal adult miceNormal lymphoid tissuesElicit graftGraft-VersusGVH reactionGVH reactivityLymph nodesRecipient spleensSpleen weightSyngeneic recipientsLymphoid tissueSpleen cellsLymphoid cellsAdult miceHost reactionHost responseNormal populationDistinct subpopulationsSubpopulationsFunctional heterogeneitySpleenGraft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors.
Tigelaar R, Asofsky R. Graft-vs-host reactivity of mouse thymocytes: effect of cortisone pretreatment of donors. The Journal Of Immunology 1973, 110: 567-74. PMID: 4405321, DOI: 10.4049/jimmunol.110.2.567.Peer-Reviewed Original ResearchConceptsSpleen weightNormal thymocytesPeripheral lymph node cellsCell-mediated immune reactionsBALB/c miceLymph node cellsThymus-derived cellsCortisone-resistant thymocytesLymphoid cell populationsCortisone pretreatmentGVH reactivityHost reactivityC miceNode cellsNormal donorsImmune reactionsThymus cellsCortisone acetateCumulative mortalityThymocytesMortalityUnique populationCell populationsMouse thymocytesDistinct cell types
1972
KINETICS OF GRAFT-VERSUS-HOST SPLENOMEGALY IN NEONATAL F1 RECIPIENTS OF PARENTAL STRAIN MOUSE LYMPH NODE CELLS AND/OR THYMOCYTES
Tigelaar R, Asofsky R. KINETICS OF GRAFT-VERSUS-HOST SPLENOMEGALY IN NEONATAL F1 RECIPIENTS OF PARENTAL STRAIN MOUSE LYMPH NODE CELLS AND/OR THYMOCYTES. Transplantation 1972, 14: 805-807. PMID: 4404987, DOI: 10.1097/00007890-197212000-00025.Peer-Reviewed Original ResearchSYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1972, 135: 1059-1070. PMID: 4401814, PMCID: PMC2138974, DOI: 10.1084/jem.135.5.1059.Peer-Reviewed Original Research