1995
Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma
Longley J, Tyrrell L, Lu S, Farrell J, Ding T, Yan S, Sallee D, Heald P, Berger C, Tigelaar R, Edelson R. Malignant and Normal T Cells Show Random Use of T-Cell Receptor ∝ Chain Variable Regions in Patients with Cutaneous T-Cell Lymphoma. Journal Of Investigative Dermatology 1995, 105: 62-64. PMID: 7615977, DOI: 10.1111/1523-1747.ep12312571.Peer-Reviewed Original ResearchConceptsCutaneous T-cell lymphomaT-cell lymphomaT cell receptorMalignant cellsRegion usagePathogenesis of CTCLNormal peripheral blood lymphocytesV region usagePeripheral blood lymphocytesNormal T cellsTCR V regionsMature T lymphocytesBeta-chain transcriptsBeta usageChain transcriptsOligoclonal patternAlpha usePeripheral bloodLeukemic patientsPolymerase chain reactionBlood lymphocytesChronic stimulationMalignant lymphocytesT cellsT lymphocytes
1992
Expression of mouse Tla region class I genes in tissue enriched for γδ cells
Eghtesady P, Brorson K, Cheroutre H, Tigelaar R, Hood L, Kronenberg M. Expression of mouse Tla region class I genes in tissue enriched for γδ cells. Immunogenetics 1992, 36: 377-388. PMID: 1388139, DOI: 10.1007/bf00218045.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalBase SequenceBlotting, NorthernDNA ProbesFetusGene ExpressionGenes, MHC Class IMiceMice, Inbred BALB CMice, Inbred C57BLMolecular Sequence DataMultigene FamilyPolymerase Chain ReactionReceptors, Antigen, T-Cell, gamma-deltaRepetitive Sequences, Nucleic AcidT-LymphocytesConceptsΓδ T cellsT cellsPolymerase chain reactionTla region genesClass IΓδ T lymphocytesPresentation of antigensThymus leukemia antigenMajor histocompatibility complexRegion gene productsΓδ cellsLeukemia antigenAntigen presentationT lymphocytesRegion genesFetal tissuesTL antigensMouse major histocompatibility complexMonoclonal antibodiesHistocompatibility complexPattern of expressionAntigenChain reactionRecent evidenceNorthern blot analysis
1987
Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells
Kuziel W, Takashima A, Bonyhadi M, Bergstresser P, Allison J, Tigelaar R, Tucker P. Regulation of T-cell receptor γ-chain RNA expression in murine Thy-1+ dendritic epidermal cells. Nature 1987, 328: 263-266. PMID: 2885757, DOI: 10.1038/328263a0.Peer-Reviewed Original ResearchConceptsEpidermal cellsT cell receptorDendritic epidermal cellsThy-1Steady-state levelsMurine Thy-1T lymphocytesCell differentiationT-cell lineageT cell differentiationDistinct populationsMost T lymphocytesRNA expressionMajor histocompatibility complexΔ complexNecessary eventΑ-chainΓ-chainMinor populationDendritic cellsLangerhans cellsExpressionCellsNormal miceHistocompatibility complexLack of dendritic Thy-1+ epidermal cells in mice with severe combined immunodeficiency disease.
Nixon-Fulton J, Witte P, Tigelaar R, Bergstresser P, Kumar V. Lack of dendritic Thy-1+ epidermal cells in mice with severe combined immunodeficiency disease. The Journal Of Immunology 1987, 138: 2902-5. PMID: 2883236, DOI: 10.4049/jimmunol.138.9.2902.Peer-Reviewed Original ResearchConceptsDendritic Thy-1SCID miceEpidermal cell suspensionsThy-1NK cellsT lymphocytesEpidermal whole mountsSevere combined immunodeficiency diseaseCombined immunodeficiency diseaseNormal bone marrowControl miceImmunodeficiency diseaseBone marrowWhole mountsMiceImmunofluorescent stainingCon ACell suspensionsEC suspensionsEpidermal cellsLymphocytesPrecursor levelsCellsTransplantationMarrow
1985
Origin and Function of Thy-1+ Dendritic Epidermal Cells in Mice
Bergstresser P, Sullivan S, Streilein J, Tigelaar R. Origin and Function of Thy-1+ Dendritic Epidermal Cells in Mice. Journal Of Investigative Dermatology 1985, 85: s85-s90. PMID: 2409184, DOI: 10.1111/1523-1747.ep12275516.Peer-Reviewed Original ResearchConceptsLangerhans cellsFluorescence Activated Cell SorterDendritic epidermal cellsNatural suppressor cellsNatural killer cellsAntigen-presenting cellsEpidermal Langerhans cellsCells/mm2Bone marrow originThy-1 antigenNormal mouse skinCell surface determinantsBone marrow cellsSuppressor cellsCutaneous sitesDendritic cellsKiller cellsMonoclonal antibody 20T lymphocytesLymphoreticular cellsMarrow originAsialo GM1Vascular sourceThy-1Marrow cells
1984
The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes
Piepkorn M, Tigelaar R. The Intracutaneous Growth of Murine Lymphomas: Epidermal Invasion Is Characteristic of Multiple Tumor Phenotypes. Journal Of Investigative Dermatology 1984, 83: 281-285. PMID: 6237158, DOI: 10.1111/1523-1747.ep12340368.Peer-Reviewed Original ResearchConceptsMycosis fungoidesT cellsHelper/inducer T cellsCutaneous T-cell lymphomaT cell surface phenotypeInducer T cellsBALB/c originT-cell lymphomaMalignant T cellsLymphoid cell subsetsEosin-stained sectionsCenter of tumorT cell linesCytotoxic markersSézary syndromeCell subsetsBenign dermatosesDermal-epidermal junctionEpidermal necrosisParallel groupIntradermal injectionT lymphocytesSyngeneic miceSurface phenotypeLymphoid cells
1983
Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis
Bergstresser P, Tigelaar R, Dees J, Streilein J. Thy-1 Antigen-Bearing Dendritic Cells Populate Murine Epidermis. Journal Of Investigative Dermatology 1983, 81: 286-288. PMID: 6136547, DOI: 10.1111/1523-1747.ep12518332.Peer-Reviewed Original ResearchConceptsLangerhans cellsMurine epidermisCutaneous T-cell lymphomaEar epidermisDendritic cell populationsStrain BALB/cT-cell lymphomaEpidermal Langerhans cellsThy-1.2 antigenBALB/cCell populationsThy-1 antigenT lymphocytesIa antigensDistinct cell populationsMalignant counterpartsThy-1Monoclonal antibodiesStrain B10.AAntigenMelanocytesImmunofluorescence microscopySkin surfaceEpidermisMature melanocytes