1990
Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity.
Cruz P, Tigelaar R, Bergstresser P. Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity. The Journal Of Immunology 1990, 144: 2486-92. PMID: 1969448, DOI: 10.4049/jimmunol.144.7.2486.Peer-Reviewed Original ResearchConceptsLow-dose UVB radiationContact hypersensitivityLangerhans cellsIntravenous infusionLow-dose ultraviolet B (UVB) radiationExposure of LCThy-1UVB radiationSuppressor signalsMesenteric lymph nodesLow-dose UVBEffector signalsSkin graft experimentsLC migrationImmunologic targetsLymph nodesAllogeneic transferCH responsesLymphoid tissueImmune responseSyngeneic miceImmunization modelImmunogenic propertiesInfusionUltraviolet B radiationUVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice
Glass M, Bergstresser P, Tigelaar R, Streilein J. UVB Radiation and DNFB Skin Painting Induce Suppressor Cells Universally in Mice. Journal Of Investigative Dermatology 1990, 94: 273-278. PMID: 1689757, DOI: 10.1111/1523-1747.ep12874117.Peer-Reviewed Original ResearchConceptsSuppressor T cellsStrains of miceContact hypersensitivityLangerhans cellsT cellsSuppressor cellsHapten-specific suppressor T cellsInduction of CHSUVB-susceptible strainsT suppressor cellsTreatment of miceAntigen-presenting cellsEpidermal Langerhans cellsEffects of UVBEffector mechanismsMurine skinMiceUVBUVB radiationSkinInductionDinitrofluorobenzeneCellsUVRApparent effect
1989
Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity
Cruz P, Nixon-Fulton J, Tigelaar R, Bergstresser P. Disparate Effects of In Vitro Low-Dose UVB Irradiation on Intravenous Immunization with Purified Epidermal Cell Subpopulations for the Induction of Contact Hypersensitivity. Journal Of Investigative Dermatology 1989, 92: 160-165. PMID: 2918229, DOI: 10.1111/1523-1747.ep12276682.Peer-Reviewed Original ResearchConceptsIntravenous immunizationCH responsesLow-dose UVB irradiationUVB irradiationLow-dose UVB radiationC3H/HeJ miceLow-dose ultraviolet B irradiationModel of immunosuppressionAntigen-presenting functionContact hypersensitivity reactionCapacity of ECUltraviolet B irradiationContact hypersensitivityEffects of UVBSubsequent immunizationHypersensitivity reactionsHeJ miceLeft earEpidermal cell subpopulationsSyngeneic miceRight earPanel of miceDay 14Day 0Abdominal skin
1988
Local effects of UV radiation on immunization with contact sensitizers. I. Down-regulation of contact hypersensitivity by application of TNCB to UV-irradiated skin.
Cruz P, Nixon-Fulton J, Tigelaar R, Bergstresser P. Local effects of UV radiation on immunization with contact sensitizers. I. Down-regulation of contact hypersensitivity by application of TNCB to UV-irradiated skin. Photodermatology Photoimmunology & Photomedicine 1988, 5: 126-32. PMID: 3174491.Peer-Reviewed Original ResearchConceptsContact hypersensitivityNon-irradiated skinNormal skinApplication of trinitrochlorobenzeneEar-swelling responseUVB-treated miceUV-irradiated skinDaily dosesSuccessful immunizationContact sensitizersC3H miceSite of irradiationFinal exposureTrinitrochlorobenzeneLow dosesAbdominal skinImmunogenic propertiesMiceHypersensitivityImmunizationMouse skinSensitization reactionsDosesSuccessive daysSkin
1986
Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells.
Sullivan S, Bergstresser P, Tigelaar R, Streilein J. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. The Journal Of Immunology 1986, 137: 2460-7. PMID: 2876041, DOI: 10.4049/jimmunol.137.8.2460.Peer-Reviewed Original ResearchConceptsContact hypersensitivityBone marrow-derived populationLangerhans cellsThy-1Epicutaneous applicationInduction of CHSRegulation of CHSDendritic epidermal cellsRoute of immunizationEpidermal Langerhans cellsSpecific unresponsivenessAntigenic encounterCH responsesImmunogenic signalsSyngeneic miceImmunogenic capacityAntigenic signalIntact skinMouse skinCellular elementsEpidermal cellsHypersensitivityMiceCell typesInduction
1983
Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation.
Elmets C, Bergstresser P, Tigelaar R, Wood P, Streilein J. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. Journal Of Experimental Medicine 1983, 158: 781-794. PMID: 6193234, PMCID: PMC2187099, DOI: 10.1084/jem.158.3.781.Peer-Reviewed Original ResearchConceptsTolerogenic signalsLow-dose ultraviolet B (UVB) radiationLow-dose ultraviolet radiationAntigen-presenting potentialAntigen-specific unresponsivenessResident Langerhans cellsMechanism of unresponsivenessSuppressor cellsContact hypersensitivityLyt-1Effector stageLangerhans cellsSystemic administrationT cellsLocal applicationUltraviolet B radiationInduction phaseB radiationUnresponsivenessSkinUltraviolet radiationCellsTolerogenDNFBHypersensitivity
1982
Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity.
Tigelaar R, Bergstresser P, Lonsberry L, Elmets C, Wood P, Streilen J. Oral ingestion of epicutaneously applied hapten in mice may unwittingly induce down-regulation of contact hypersensitivity. The Journal Of Immunology 1982, 129: 1898-904. PMID: 6749982, DOI: 10.4049/jimmunol.129.5.1898.Peer-Reviewed Original Research